diff --git a/lisp/ob-python.el b/lisp/ob-python.el
index 0e0539d7a..c15d45b96 100644
--- a/lisp/ob-python.el
+++ b/lisp/ob-python.el
@@ -400,28 +400,31 @@ by `org-babel-comint-async-filter'."
    session (current-buffer)
    "ob_comint_async_python_\\(.+\\)_\\(.+\\)"
    'org-babel-chomp 'org-babel-python-async-value-callback)
-  (let ((python-shell-buffer-name (org-babel-python-without-earmuffs session)))
-    (pcase result-type
-      (`output
-       (let ((uuid (org-id-uuid)))
-         (with-temp-buffer
-           (insert (format org-babel-python-async-indicator "start" uuid))
-           (insert "\n")
-           (insert body)
-           (insert "\n")
-           (insert (format org-babel-python-async-indicator "end" uuid))
-           (python-shell-send-buffer))
-         uuid))
-      (`value
-       (let ((tmp-results-file (org-babel-temp-file "python-"))
-             (tmp-src-file (org-babel-temp-file "python-")))
-         (with-temp-file tmp-src-file (insert body))
-         (with-temp-buffer
-           (insert (org-babel-python-format-session-value tmp-src-file tmp-results-file result-params))
-           (insert "\n")
-           (insert (format org-babel-python-async-indicator "file" tmp-results-file))
-           (python-shell-send-buffer))
-         tmp-results-file)))))
+  (pcase result-type
+    (`output
+     (let ((uuid (org-id-uuid)))
+       (with-temp-buffer
+         (insert (format org-babel-python-async-indicator "start" uuid))
+         (insert "\n")
+         (insert body)
+         (insert "\n")
+         (insert (format org-babel-python-async-indicator "end" uuid))
+         (let ((python-shell-buffer-name
+                (org-babel-python-without-earmuffs session)))
+           (python-shell-send-buffer)))
+       uuid))
+    (`value
+     (let ((tmp-results-file (org-babel-temp-file "python-"))
+           (tmp-src-file (org-babel-temp-file "python-")))
+       (with-temp-file tmp-src-file (insert body))
+       (with-temp-buffer
+         (insert (org-babel-python-format-session-value tmp-src-file tmp-results-file result-params))
+         (insert "\n")
+         (insert (format org-babel-python-async-indicator "file" tmp-results-file))
+         (let ((python-shell-buffer-name
+                (org-babel-python-without-earmuffs session)))
+           (python-shell-send-buffer)))
+       tmp-results-file))))
 
 (provide 'ob-python)
 
diff --git a/testing/lisp/test-ob-python.el b/testing/lisp/test-ob-python.el
index 7aac87116..82fbca36e 100644
--- a/testing/lisp/test-ob-python.el
+++ b/testing/lisp/test-ob-python.el
@@ -296,6 +296,20 @@ print(list(range(3)))
                      (string= (concat src-block result)
                               (buffer-string)))))))
 
+(ert-deftest test-ob-python/async-local-python-shell ()
+  ;; Disable the test on older Emacs as built-in python.el sometimes
+  ;; fail to initialize session.
+  (skip-unless (version<= "28" emacs-version))
+  (when-let ((buf (get-buffer "*Python*")))
+    (let (kill-buffer-query-functions)
+      (kill-buffer buf)))
+  (org-test-with-temp-text-in-file
+      "# -*- python-shell-buffer-name: \"Python 3\" -*-
+<point>#+begin_src python :session \"*Python 3*\" :async yes
+1
+#+end_src"
+    (should (org-babel-execute-src-block))))
+
 (provide 'test-ob-python)
 
 ;;; test-ob-python.el ends here