diff --git a/tex/thesis.tex b/tex/thesis.tex index 4757c1a..a16d82a 100644 --- a/tex/thesis.tex +++ b/tex/thesis.tex @@ -2168,7 +2168,7 @@ Venn diagram from the venn R package. \section{results} -\subsection{DOE shows optimal conditions for expanded potent T cells} +\subsection{T cells can be grown on DMSs with lower IL2 concentrations} % TODO this plots proportions look dumb \begin{figure*}[ht!] @@ -2194,6 +2194,10 @@ Venn diagram from the venn R package. \label{fig:il2_mod} \end{figure*} +% TODO this is not consistent with the next section since the responses are +% different +\subsection{DOE shows optimal conditions for expanded potent T cells} + % TODO not all of these were actually use, explain why by either adding columns % or marking with an asterisk \begin{table}[!h] \centering @@ -2284,14 +2288,15 @@ process (Fig.1d-e). \end{table} SR models achieved the highest predictive performance (R2>93\%) when using -multi-omics predictors for all endpoint responses (\cref{tab:mod_results}). SR achieved R2>98\% -while GBM tree-based ensembles showed leave-one-out cross-validated R2 (LOO-R2) ->95\% for CD4+ and CD4+/CD8+ TN+TCM responses. Similarly, LASSO, PLSR, and SVM -methods showed consistent high LOO-R2, 92.9\%, 99.7\%, and 90.5\%, respectively, -to predict the CD4+/CD8+ TN+TCM. Yet, about 10\% reduction in LOO-R2, -72.5\%-81.7\%, was observed for CD4+ TN+TCM with these three methods. Lastly, SR -and PLSR achieved R2>90\% while other ML methods exhibited exceedingly variable -LOO-R2 (0.3\%,RF-51.5\%,LASSO) for CD8+ TN+TCM cells. +multi-omics predictors for all endpoint responses (\cref{tab:mod_results}). SR +achieved R2>98\% while GBM tree-based ensembles showed leave-one-out +cross-validated R2 (LOO-R2) >95\% for CD4+ and CD4+/CD8+ TN+TCM responses. +Similarly, LASSO, PLSR, and SVM methods showed consistent high LOO-R2, 92.9\%, +99.7\%, and 90.5\%, respectively, to predict the CD4+/CD8+ TN+TCM. Yet, about +10\% reduction in LOO-R2, 72.5\%-81.7\%, was observed for CD4+ TN+TCM with these +three methods. Lastly, SR and PLSR achieved R2>90\% while other ML methods +exhibited exceedingly variable LOO-R2 (0.3\%,RF-51.5\%,LASSO) for CD8+ TN+TCM +cells. % FIGURE the CD4/CD8 model results using SR