diff --git a/tex/thesis.tex b/tex/thesis.tex index 5a4b260..9b7fccd 100644 --- a/tex/thesis.tex +++ b/tex/thesis.tex @@ -97,6 +97,7 @@ \newacronym{gvhd}{GVHD}{graft-vs-host disease} \newacronym{bcma}{BCMA}{B-cell maturation antigen} \newacronym{di}{DI}{deionized} +\newacronym{moi}{MOI}{multiplicity of infection} %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % SI units for uber nerds @@ -160,7 +161,8 @@ \newcommand{\ptmemh}{\pth\ptmem} \newcommand{\ptmemk}{\ptk\ptmem} \newcommand{\dpthp}{$\Updelta$\pthp{}} -\newcommand{\carp}{\gls{car}+~\si{\percent}} +\newcommand{\ptcar}{\gls{car}+} +\newcommand{\ptcarp}{\ptcar~\si{\percent}} \newcommand{\catnum}[2]{(#1, #2)} \newcommand{\product}[3]{#1 \catnum{#2}{#3}} @@ -1433,7 +1435,13 @@ showing that migration was likely independent of \gls{car} transduction. \label{fig:car_production} \end{figure*} -% RESULT bcma stuff +In addition to CD19 \gls{car} T cells, we also demonstrated that the \gls{dms} +platform can be used to expand \gls{car} T cells against \gls{bcma}. Analogously +to the case with CD19, \gls{dms} and bead produced similar fractions of \ptcar{} +cells (albeit in this case at day 7 and with an undefined \gls{moi}) +(\cref{fig:car_bcma_percent}). Also consistent with CD19 and non-\gls{car} data, +we also found that the number of \ptcar{} T cells was greater for \gls{dms} than +for bead (\cref{fig:car_bcma_total}). % TODO the right half if bigger than the left half % TODO add memory stuff to this since I have it (it wasn't the right size so I @@ -1449,8 +1457,8 @@ showing that migration was likely independent of \gls{car} transduction. \caption[BMCA Transduction Results] {\glspl{dms} produce larger numbers of \gls{bcma} \gls{car} T cells compared to beads. - \subcap{fig:car_bcma_percent}{\carp{} at day 14.} - \subcap{fig:car_bcma_total}{Total number of \carp{} cells at day 14.} + \subcap{fig:car_bcma_percent}{\ptcarp{} at day 14.} + \subcap{fig:car_bcma_total}{Total number of \ptcarp{} cells at day 14.} } \label{fig:car_bcma} \end{figure*} @@ -2267,7 +2275,7 @@ cells are effective at lower doses. \subcap{fig:mouse_timecourse_qc_growth}{Fold change of T cells (each timepoint only includes the runs that were harvested at day 14).} Fractions of T cell subtypes in the day 14 product including - \subcap{fig:mouse_timecourse_qc_car}{\carp{}}, + \subcap{fig:mouse_timecourse_qc_car}{\ptcarp{}}, \subcap{fig:mouse_timecourse_qc_cd4}{\pthp{}}, and \subcap{fig:mouse_timecourse_qc_mem}{\ptmemp{}}. }