From 67a4758da01318e9818d61fba5ae8eac78ffa0ce Mon Sep 17 00:00:00 2001
From: ndwarshuis <ndwar@yavin4.ch>
Date: Tue, 27 Jul 2021 17:53:07 -0400
Subject: [PATCH] ADD small para on bcma

---
 tex/thesis.tex | 18 +++++++++++++-----
 1 file changed, 13 insertions(+), 5 deletions(-)

diff --git a/tex/thesis.tex b/tex/thesis.tex
index 5a4b260..9b7fccd 100644
--- a/tex/thesis.tex
+++ b/tex/thesis.tex
@@ -97,6 +97,7 @@
 \newacronym{gvhd}{GVHD}{graft-vs-host disease}
 \newacronym{bcma}{BCMA}{B-cell maturation antigen}
 \newacronym{di}{DI}{deionized}
+\newacronym{moi}{MOI}{multiplicity of infection}
 
 %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
 % SI units for uber nerds
@@ -160,7 +161,8 @@
 \newcommand{\ptmemh}{\pth\ptmem}
 \newcommand{\ptmemk}{\ptk\ptmem}
 \newcommand{\dpthp}{$\Updelta$\pthp{}}
-\newcommand{\carp}{\gls{car}+~\si{\percent}}
+\newcommand{\ptcar}{\gls{car}+}
+\newcommand{\ptcarp}{\ptcar~\si{\percent}}
 
 \newcommand{\catnum}[2]{(#1, #2)}
 \newcommand{\product}[3]{#1 \catnum{#2}{#3}}
@@ -1433,7 +1435,13 @@ showing that migration was likely independent of \gls{car} transduction.
   \label{fig:car_production}
 \end{figure*}
 
-% RESULT bcma stuff
+In addition to CD19 \gls{car} T cells, we also demonstrated that the \gls{dms}
+platform can be used to expand \gls{car} T cells against \gls{bcma}. Analogously
+to the case with CD19, \gls{dms} and bead produced similar fractions of \ptcar{}
+cells (albeit in this case at day 7 and with an undefined \gls{moi})
+(\cref{fig:car_bcma_percent}). Also consistent with CD19 and non-\gls{car} data,
+we also found that the number of \ptcar{} T cells was greater for \gls{dms} than
+for bead (\cref{fig:car_bcma_total}).
 
 % TODO the right half if bigger than the left half
 % TODO add memory stuff to this since I have it (it wasn't the right size so I
@@ -1449,8 +1457,8 @@ showing that migration was likely independent of \gls{car} transduction.
   \caption[BMCA Transduction Results]
   {\glspl{dms} produce larger numbers of \gls{bcma} \gls{car} T cells compared
     to beads.
-    \subcap{fig:car_bcma_percent}{\carp{} at day 14.}
-    \subcap{fig:car_bcma_total}{Total number of \carp{} cells at day 14.}
+    \subcap{fig:car_bcma_percent}{\ptcarp{} at day 14.}
+    \subcap{fig:car_bcma_total}{Total number of \ptcarp{} cells at day 14.}
   }
   \label{fig:car_bcma}
 \end{figure*}
@@ -2267,7 +2275,7 @@ cells are effective at lower doses.
     \subcap{fig:mouse_timecourse_qc_growth}{Fold change of T cells (each
       timepoint only includes the runs that were harvested at day 14).}
     Fractions of T cell subtypes in the day 14 product including
-    \subcap{fig:mouse_timecourse_qc_car}{\carp{}},
+    \subcap{fig:mouse_timecourse_qc_car}{\ptcarp{}},
     \subcap{fig:mouse_timecourse_qc_cd4}{\pthp{}}, and
     \subcap{fig:mouse_timecourse_qc_mem}{\ptmemp{}}.
   }