diff --git a/tex/thesis.tex b/tex/thesis.tex index eb9c75c..83996ef 100644 --- a/tex/thesis.tex +++ b/tex/thesis.tex @@ -123,6 +123,10 @@ \newcommand{\cdp}[1]{\pos{\cd{#1}}} \newcommand{\cdn}[1]{\cd{#1}-} \newcommand{\ptmem}{\cdp{62L}\pos{CCR7}} +\newcommand{\pth}{\cdp{4}} +\newcommand{\ptk}{\cdp{8}} +\newcommand{\ptmemh}{\pth\ptmem} +\newcommand{\ptmemk}{\ptk\ptmem} \newcommand{\catnum}[2]{(#1, #2)} \newcommand{\product}[3]{#1 \catnum{#2}{#3}} @@ -977,7 +981,7 @@ context of pure error). Statistical significance was evaluated at $\upalpha$ = \phantomsubcaption\label{fig:dms_cells_fluor} \endgroup - \caption[\gls{dms} Reaction timing] + \caption[T cells growing on \glspl{dms}] {Cells grow in tight clusters in and around functionalized \gls{dms}. \subcap{fig:dms_cells_phase}{Phase-contrast image of T cells growing on \glspl{dms} on day 7} @@ -985,14 +989,41 @@ context of pure error). Statistical significance was evaluated at $\upalpha$ = growing on \glspl{dms} on day 9. \Glspl{dms} were stained using \gls{stppe} (red) and T cells were stained using \acd{45}-\gls{af647}.} } - \label{fig:dms_flowchart} + \label{fig:dms_cells} \end{figure*} % 3-donor expansion figure \subsection{DMSs lead to greater expansion and memory and CD4+ phenotypes} -% phenotype expansion plots +% TODO add significance tests to this +\begin{figure*}[ht!] + \begingroup + + \includegraphics{../figures/dms_vs_bead_expansion.png} + \phantomsubcaption\label{fig:dms_exp_fold_change} + \phantomsubcaption\label{fig:dms_exp_mem} + \phantomsubcaption\label{fig:dms_exp_cd4} + \phantomsubcaption\label{fig:dms_exp_mem4} + \phantomsubcaption\label{fig:dms_exp_mem8} + + \endgroup + \caption[\gls{dms} vs bead expansion] + {\gls{dms} lead to superior expansion of T cells compared to beads across + multiple donors. + \subcap{fig:dms_exp_fold_change}{Longitudinal fold change of T cells grown + using either \glspl{dms} or beads. Significance was evaulated using t + tests at each timepoint} + Fold change of subpopulations expanded using either \gls{dms} or beads at + day 14, including + \subcap{fig:dms_exp_mem}{\ptmem{} cells}, + \subcap{fig:dms_exp_cd4}{\pth{} cells}, + \subcap{fig:dms_exp_mem4}{\ptmemh{} cells}, and + \subcap{fig:dms_exp_mem8}{\ptmemk{} cells} + } + \label{fig:dms_exp} +\end{figure*} + % phenotype flow plots \subsection*{DMSs can be used to produce functional CAR T cells}