ENH say which papers I stole

This commit is contained in:
Nathan Dwarshuis 2021-08-04 21:33:15 -04:00
parent 81c03f4199
commit a5a9804f97
1 changed files with 18 additions and 11 deletions

View File

@ -29,6 +29,14 @@
urlcolor=black,
}
\newcommand{\dmspaper}{Dwarshuis et al. Functionalized microcarriers improve T
cell manufacturing by facilitating migratory memory T cell production and
increasing CD4/CD8 ratio.~2019.~biorxiv.~https://doi.org/10.1101/646760}
\newcommand{\modelpaper}{Odeh-Couvertier et al. Predicting T Cell Quality During
Manufacturing Through an Artificial Intelligence-based Integrative Multi-Omics
Analytical Platform.~2019.~biorxiv.~https://doi.org/10.1101/2021.05.05.442854}
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
% my attempt to make MATLAB code look pretty
@ -1297,7 +1305,7 @@ system to state-of-the-art T cell activation technologies for both expansion
potential and memory cell formation. The governing hypothesis was that
microcarriers functionalized with \acd{3} and \acd{28} \glspl{mab} will
provide superior expansion and memory phenotype compared to state-of-the-art
bead-based T cell expansion technology.
bead-based T cell expansion technology\footnote{adapted from \dmspaper{}}.
\section{Methods}
@ -1778,8 +1786,7 @@ validity using residual plots (to assess constant variance and independence
assumptions), QQplots and Shapiro-Wilk normality test (to assess normality
assumptions), Box-Cox plots (to assess need for power transformations), and
lack-of-fit tests where replicates were present (to assess model fit in the
context of pure error). Statistical significance was evaluated at $\upalpha$ =
0.05.
context of pure error). Significance was evaluated at $\upalpha$ = 0.05.
\subsection{Flow Cytometry}\label{sec:flow_cytometry}
@ -2745,7 +2752,7 @@ predict the outcome of the cultures. We should stress that the specific
universal, as this was not performed with equipment that would normally be used
at scale. However, the process outlined here is one that can easily be adaptable
to any system, and the specific findings themselves offer interesting insights
that warrant further study.
that warrant further study\footnote{adapted from \modelpaper{}}.
\section{Methods}
@ -4061,13 +4068,13 @@ the early work with \il{15} in mice\cite{Lodolce1998}.
The purpose of this aim was to verify that \gls{car} T cells produced using the
\gls{dms} system will show potent anti-tumor properties in a complex \invivo{}
system compared to state-of-the-art bead technology. We hypothesized that due to
the increased \ptmem{} and \pth{} phenotypes as shown in \cref{aim1}, that
\gls{dms}-expanded T cells would show longer survival and lower tumor burden
than those expanded with beads. We explored the effect of dosing at different
levels and the effect of harvesting T cells at early timepoints in the culture,
which has been shown to produce lower-differentiated T cells with higher
potency\cite{Ghassemi2018}.
system compared to state-of-the-art bead technology\footnote{adapted from
\dmspaper{}}. We hypothesized that due to the increased \ptmem{} and \pth{}
phenotypes as shown in \cref{aim1}, that \gls{dms}-expanded T cells would show
longer survival and lower tumor burden than those expanded with beads. We
explored the effect of dosing at different levels and the effect of harvesting T
cells at early timepoints in the culture, which has been shown to produce
lower-differentiated T cells with higher potency\cite{Ghassemi2018}.
\section{Methods}