diff --git a/tex/thesis.tex b/tex/thesis.tex index bdfa172..4873e30 100644 --- a/tex/thesis.tex +++ b/tex/thesis.tex @@ -157,6 +157,7 @@ \newcommand{\ptmemh}{\pth\ptmem} \newcommand{\ptmemk}{\ptk\ptmem} \newcommand{\dpthp}{$\Updelta$\pthp{}} +\newcommand{\carp}{\gls{car}+~\si{\percent}} \newcommand{\catnum}[2]{(#1, #2)} \newcommand{\product}[3]{#1 \catnum{#2}{#3}} @@ -2072,8 +2073,7 @@ cells are effective at lower doses. \subcap{fig:mouse_timecourse_qc_growth}{Fold change of T cells (each timepoint only includes the runs that were harvested at day 14).} Fractions of T cell subtypes in the day 14 product including - % TODO refactor CAR+ percent into nice macro - \subcap{fig:mouse_timecourse_qc_car}{\gls{car}+~\si{\percent}}, + \subcap{fig:mouse_timecourse_qc_car}{\carp{}}, \subcap{fig:mouse_timecourse_qc_cd4}{\pthp{}}, and \subcap{fig:mouse_timecourse_qc_mem}{\ptmemp{}}. } @@ -2103,6 +2103,22 @@ cells are effective at lower doses. \section{discussion} +When we tested bead and DMS expanded \gls{car} T cells, we also found that the +\gls{dms} expanded CAR-T cells outperformed bead groups in prolonging survival +of Nalm-6 tumor challenged (intravenously injected) \gls{nsg} mice. DMS expanded +CAR-T cells were very effective in clearing tumor cells as early as 7 days post +CAR-T injection even at low total T cell dose compared to the bead groups where +tumor burden was higher than DMS groups across all the total T cell doses tested +here. More interestingly, when only CAR-expressing T cell doses between bead and +DMS groups were compared, DMS group had significantly higher survival effects +over similar or higher CAR expression T cell doses from bead group. All these +results suggest that the higher proportion of memory T cells in DMS groups +(compared to bead group) resulted in highly effective CAR-T cells that can +efficiently kill tumor cells as recently reported in +literature\cite{Fraietta2018, Sommermeyer2015}. + +% DISCUSSION 2nd mouse model + \chapter{conclusions and future work}\label{conclusions} \section{conclusions} \section{future work}