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Nalm-6-ffluctumor cellinjection (1e6, IV) + Bioluminescenceimaging + CAR T cell injection + + + + + + + + + + + + + + + + + + + + + + + + + + + Activate(bead or DMS) + Transduce + Harvest/QC + Harvest/QC + Harvest/QC + D1 + + D6 + + D10 + + + + T cell expansion + NSG Mice + + Test T cells fromdifferent timepoints + + diff --git a/tables/mouse_dose_car.tex b/tables/mouse_dose_car.tex new file mode 100644 index 0000000..64c6e6f --- /dev/null +++ b/tables/mouse_dose_car.tex @@ -0,0 +1,10 @@ +\begin{tabular}{lcc} +\\[-1.8ex]\hline +\hline \\[-1.8ex] +\\[-1.8ex] & Dose & 1e6 T cells/mouse & 1e6 CAR T cells/mouse 1e6 (DMS) & CAR T cells/mouse (Bead) \\ +\hline \\[-1.8ex] +High & 1.25 & 0.855 & 0.315 \\ +Medium & 0.8325 & 0.570 & 0.210 \\ +Low & 3.313 & 0.214 & 0.079 \\ +\hline \\[-1.8ex] +\end{tabular} \ No newline at end of file diff --git a/tex/thesis.tex b/tex/thesis.tex index 504454b..89d007d 100644 --- a/tex/thesis.tex +++ b/tex/thesis.tex @@ -1599,6 +1599,23 @@ analyzed using GraphPad Prism using the Mantel-Cox test to assess significance between survival groups. \section{results} + +\subsection{DMS-expanded T cells show greater anti-tumor activity \invivo{} + compared to beads} + +% figure showing the experimental model and dosing strategy +% table for % CAR+ T cells injected into the mice +% figure for the mem and CAR+ percent injected into the mice +% figure showing IVIS images +% figure showing the surival curves + +\subsection{Beads and DMSs perform similarly at earlier timepoints} + +% figure showing the experimental model and dosing strategy +% figure for the mem and CAR+ percent injected into the mice +% figure showing IVIS images +% figure showing the photon plots per time + \section{discussion} \chapter{conclusions and future work}\label{conclusions}