ENH update grex memory data
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@ -67,6 +67,34 @@
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|
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<g
|
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|
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d="m 24.59,77.6 v 87"
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style="fill:none;stroke:#000000;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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</g>
|
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<g
|
|
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|
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<g
|
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<g
|
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|
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transform="matrix(1,0,0,-1,8.26,78.2)"
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style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
|
||||||
y="0"
|
|
||||||
sodipodi:role="line"
|
|
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id="tspan48368">0.0%</tspan></text>
|
|
||||||
<text
|
|
||||||
transform="matrix(1,0,0,-1,5.48,97.44)"
|
|
||||||
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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id="text48374"><tspan
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|
||||||
y="0"
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||||||
sodipodi:role="line"
|
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id="tspan48372">10.0%</tspan></text>
|
|
||||||
<text
|
|
||||||
transform="matrix(1,0,0,-1,5.48,116.68)"
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style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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y="0"
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sodipodi:role="line"
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id="tspan48376">20.0%</tspan></text>
|
|
||||||
<text
|
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transform="matrix(1,0,0,-1,5.48,135.92)"
|
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style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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sodipodi:role="line"
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|
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||||||
<text
|
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transform="matrix(1,0,0,-1,5.48,155.16)"
|
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y="0"
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sodipodi:role="line"
|
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|
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|
|
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<g
|
|
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id="g48388" />
|
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<g
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<path
|
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d="m 21.85,79.99 h 2.74"
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style="fill:none;stroke:#333333;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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<path
|
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d="m 21.85,99.23 h 2.74"
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<path
|
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<path
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<path
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d="m 21.85,156.95 h 2.74"
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</g>
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<g
|
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<g
|
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<g
|
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<g
|
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<g
|
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<g
|
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<g
|
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<path
|
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|
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</g>
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<g
|
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<g
|
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<g
|
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<path
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|
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|
|
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<path
|
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d="M 69.08,74.86 V 77.6"
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<path
|
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d="M 96.89,74.86 V 77.6"
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</g>
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<g
|
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<g
|
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id="g48432">
|
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<text
|
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transform="matrix(0,-1,-1,0,37.68,72.67)"
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style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
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x="0 3.6099999 7.2199998 10"
|
|
||||||
y="0"
|
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sodipodi:role="line"
|
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id="tspan48434">CD4+</tspan></text>
|
|
||||||
<text
|
|
||||||
transform="matrix(0,-1,-1,0,65.49,72.67)"
|
|
||||||
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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x="0 3.6099999 7.2199998 10 12.92 16.530001 20.139999 23.75 26.530001 29.450001 33.060001 36.669998 39.450001 42.23 45.009998"
|
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y="0"
|
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sodipodi:role="line"
|
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id="tspan48438">CD4+CCR7+CD62L+</tspan></text>
|
|
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<text
|
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||||||
transform="matrix(0,-1,-1,0,93.3,72.67)"
|
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style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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x="0 3.6099999 7.2199998 10 12.92 16.530001 20.139999 23.75 26.530001 29.450001 33.060001 36.669998 39.450001 42.23 45.009998"
|
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y="0"
|
|
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sodipodi:role="line"
|
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id="tspan48442">CD8+CCR7+CD62L+</tspan></text>
|
|
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</g>
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<g
|
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id="g48446" />
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<g
|
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<g
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<g
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<g
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<g
|
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<g
|
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id="g48458" />
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<g
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<g
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<g
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<g
|
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<g
|
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<g
|
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<g
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<g
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<g
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<path
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d="m 31.23,5.48 h 75.7 v 13.59 h -75.7 z"
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style="fill:#ffffff;fill-opacity:1;fill-rule:nonzero;stroke:none"
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</g>
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<g
|
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<g
|
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<g
|
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<g
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<text
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transform="matrix(1,0,0,-1,34.06,10.12)"
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x="0 4.9980001 8.3339996 10.002 13.338 16.674"
|
|
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|
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sodipodi:role="line"
|
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|
|
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</g>
|
|
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<g
|
|
||||||
id="g48492" />
|
|
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<g
|
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<g
|
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id="g48496" />
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<g
|
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id="g48498" />
|
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<g
|
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id="g48500">
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<path
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</g>
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<g
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<g
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<g
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<g
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<path
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<g
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<g
|
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<g
|
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|
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<text
|
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|
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|
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|
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|
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sodipodi:role="line"
|
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id="tspan48522">bead</tspan></text>
|
|
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</g>
|
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<g
|
|
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id="g48526" />
|
|
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<g
|
|
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id="g48528" />
|
|
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<g
|
|
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id="g48530" />
|
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<g
|
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<g
|
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id="g48534">
|
|
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<text
|
|
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transform="matrix(1,0,0,-1,92.99,10.48)"
|
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style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#000000;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
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|
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|
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sodipodi:role="line"
|
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id="tspan48536">DMS</tspan></text>
|
|
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</g>
|
|
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<g
|
|
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id="g48540" />
|
|
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<g
|
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<g
|
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<g
|
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<g
|
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<g
|
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|
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|
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<g
|
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|
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<g
|
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|
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<g
|
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<text
|
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xml:space="preserve"
|
xml:space="preserve"
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style="font-size:16px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
|
style="font-size:16px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
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|
|
@ -1942,5 +1358,318 @@
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id="tspan53549"
|
id="tspan53549"
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x="354.00003"
|
x="354.00003"
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y="12.000001">c.</tspan></text>
|
y="12.000001">c.</tspan></text>
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|
<g
|
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|
id="g61206"
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|
inkscape:label="total_memory_phenotype"
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<g
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id="g61208">
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|
<path
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|
d="M 0,0 H 113.39 V 90.71 H 0 Z"
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style="fill:#ffffff;fill-opacity:1;fill-rule:nonzero;stroke:none"
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</g>
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<g
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<g
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<g
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<g
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<g
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d="M 0,0 H 113.39 V 90.71 H 0 Z"
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|
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|
id="path61234" />
|
||||||
|
</g>
|
||||||
|
</g>
|
||||||
|
<g
|
||||||
|
id="g61236" />
|
||||||
|
<g
|
||||||
|
id="g61238">
|
||||||
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<g
|
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id="g61240"
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clip-path="url(#clipPath61244)">
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|
<path
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d="M 32.95,15.1 H 107.9 V 85.23 H 32.95 Z"
|
||||||
|
style="fill:#ffffff;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
||||||
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<path
|
||||||
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d="m 53.4,55.31 v 6.3"
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|
||||||
|
<path
|
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d="M 53.4,50.42 V 46.34"
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|
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<path
|
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d="m 41.47,55.31 v -4.89 h 23.85 v 4.89 z"
|
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|
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|
||||||
|
<path
|
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|
d="M 41.47,52.63 H 65.32"
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<path
|
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d="m 85.51,36.54 c 0,1.08 0.88,1.96 1.95,1.96 1.08,0 1.96,-0.88 1.96,-1.96 0,-1.07 -0.88,-1.95 -1.96,-1.95 -1.07,0 -1.95,0.88 -1.95,1.95"
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style="fill:#000000;fill-opacity:1;fill-rule:nonzero;stroke:#000000;stroke-width:0.71;stroke-linecap:round;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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id="path61256" />
|
||||||
|
<path
|
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|
d="m 87.46,31.34 v 2.79"
|
||||||
|
style="fill:none;stroke:#000000;stroke-width:1.07;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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|
||||||
|
<path
|
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|
d="M 87.46,29.44 V 28.07"
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<path
|
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d="m 75.54,31.34 v -1.9 h 23.85 v 1.9 z"
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style="fill:#ffffff;fill-opacity:1;fill-rule:nonzero;stroke:#000000;stroke-width:1.07;stroke-linecap:round;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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<path
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d="M 75.54,29.84 H 99.39"
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style="fill:none;stroke:#000000;stroke-width:2.13;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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<text
|
||||||
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transform="matrix(1,0,0,-1,45.46,82.04)"
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style="font-variant:normal;font-weight:normal;font-size:4px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#000000;fill-opacity:1;fill-rule:nonzero;stroke:none"
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id="text61268"><tspan
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x="0 3.776 4.664 5.552 7.552 9.6560001 11.656 13.88 16.104 17.216 18.327999 20.552 21.664 24 25.112 27.336 28.448 30.672001 32.896 35.231998 37.456001"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
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|
id="tspan61266">Wilcoxon, p = 1.1e−05</tspan></text>
|
||||||
|
</g>
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|
</g>
|
||||||
|
<g
|
||||||
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<g
|
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|
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<g
|
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|
id="g61274" />
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<g
|
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id="g61276" />
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<g
|
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<g
|
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|
id="g61280" />
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<g
|
||||||
|
id="g61282" />
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<g
|
||||||
|
id="g61284" />
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||||||
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<g
|
||||||
|
id="g61286" />
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<g
|
||||||
|
id="g61288" />
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<g
|
||||||
|
id="g61290" />
|
||||||
|
<g
|
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|
id="g61292" />
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<g
|
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|
id="g61294">
|
||||||
|
<path
|
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d="M 32.95,15.1 V 85.23"
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||||||
|
style="fill:none;stroke:#000000;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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|
id="path61296" />
|
||||||
|
</g>
|
||||||
|
<g
|
||||||
|
id="g61298" />
|
||||||
|
<g
|
||||||
|
id="g61300" />
|
||||||
|
<g
|
||||||
|
id="g61302">
|
||||||
|
<text
|
||||||
|
transform="matrix(1,0,0,-1,16.63,16.49)"
|
||||||
|
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
id="text61306"><tspan
|
||||||
|
x="0 2.78 4.1700001 6.9499998"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
||||||
|
id="tspan61304">0.0%</tspan></text>
|
||||||
|
<text
|
||||||
|
transform="matrix(1,0,0,-1,16.63,29.24)"
|
||||||
|
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
id="text61310"><tspan
|
||||||
|
x="0 2.78 4.1700001 6.9499998"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
||||||
|
id="tspan61308">5.0%</tspan></text>
|
||||||
|
<text
|
||||||
|
transform="matrix(1,0,0,-1,13.85,41.99)"
|
||||||
|
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
id="text61314"><tspan
|
||||||
|
x="0 2.78 5.5599999 6.9499998 9.7299995"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
||||||
|
id="tspan61312">10.0%</tspan></text>
|
||||||
|
<text
|
||||||
|
transform="matrix(1,0,0,-1,13.85,54.75)"
|
||||||
|
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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id="text61318"><tspan
|
||||||
|
x="0 2.78 5.5599999 6.9499998 9.7299995"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
||||||
|
id="tspan61316">15.0%</tspan></text>
|
||||||
|
<text
|
||||||
|
transform="matrix(1,0,0,-1,13.85,67.5)"
|
||||||
|
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
id="text61322"><tspan
|
||||||
|
x="0 2.78 5.5599999 6.9499998 9.7299995"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
||||||
|
id="tspan61320">20.0%</tspan></text>
|
||||||
|
<text
|
||||||
|
transform="matrix(1,0,0,-1,13.85,80.25)"
|
||||||
|
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
id="text61326"><tspan
|
||||||
|
x="0 2.78 5.5599999 6.9499998 9.7299995"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
||||||
|
id="tspan61324">25.0%</tspan></text>
|
||||||
|
</g>
|
||||||
|
<g
|
||||||
|
id="g61328" />
|
||||||
|
<g
|
||||||
|
id="g61330">
|
||||||
|
<path
|
||||||
|
d="m 30.21,18.29 h 2.74"
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||||||
|
style="fill:none;stroke:#333333;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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|
id="path61332" />
|
||||||
|
<path
|
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|
d="m 30.21,31.04 h 2.74"
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|
style="fill:none;stroke:#333333;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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|
id="path61334" />
|
||||||
|
<path
|
||||||
|
d="m 30.21,43.79 h 2.74"
|
||||||
|
style="fill:none;stroke:#333333;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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id="path61336" />
|
||||||
|
<path
|
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|
d="m 30.21,56.54 h 2.74"
|
||||||
|
style="fill:none;stroke:#333333;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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|
id="path61338" />
|
||||||
|
<path
|
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|
d="m 30.21,69.29 h 2.74"
|
||||||
|
style="fill:none;stroke:#333333;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
|
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|
id="path61340" />
|
||||||
|
<path
|
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|
d="m 30.21,82.04 h 2.74"
|
||||||
|
style="fill:none;stroke:#333333;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
|
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|
id="path61342" />
|
||||||
|
</g>
|
||||||
|
<g
|
||||||
|
id="g61344" />
|
||||||
|
<g
|
||||||
|
id="g61346" />
|
||||||
|
<g
|
||||||
|
id="g61348" />
|
||||||
|
<g
|
||||||
|
id="g61350" />
|
||||||
|
<g
|
||||||
|
id="g61352" />
|
||||||
|
<g
|
||||||
|
id="g61354" />
|
||||||
|
<g
|
||||||
|
id="g61356">
|
||||||
|
<path
|
||||||
|
d="m 32.95,15.1 h 74.96"
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||||||
|
style="fill:none;stroke:#000000;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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|
id="path61358" />
|
||||||
|
</g>
|
||||||
|
<g
|
||||||
|
id="g61360" />
|
||||||
|
<g
|
||||||
|
id="g61362" />
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||||||
|
<g
|
||||||
|
id="g61364">
|
||||||
|
<path
|
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d="M 53.4,12.36 V 15.1"
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||||||
|
style="fill:none;stroke:#333333;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
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|
id="path61366" />
|
||||||
|
<path
|
||||||
|
d="M 87.46,12.36 V 15.1"
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||||||
|
style="fill:none;stroke:#333333;stroke-width:0.43;stroke-linecap:butt;stroke-linejoin:round;stroke-miterlimit:10;stroke-dasharray:none;stroke-opacity:1"
|
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|
id="path61368" />
|
||||||
|
</g>
|
||||||
|
<g
|
||||||
|
id="g61370" />
|
||||||
|
<g
|
||||||
|
id="g61372">
|
||||||
|
<text
|
||||||
|
transform="matrix(1,0,0,-1,47.84,6.58)"
|
||||||
|
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
id="text61376"><tspan
|
||||||
|
x="0 3.6099999 7.7750001"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
||||||
|
id="tspan61374">DMS</tspan></text>
|
||||||
|
<text
|
||||||
|
transform="matrix(1,0,0,-1,81.9,6.58)"
|
||||||
|
style="font-variant:normal;font-weight:normal;font-size:5px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#4d4d4d;fill-opacity:1;fill-rule:nonzero;stroke:none"
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|
id="text61380"><tspan
|
||||||
|
x="0 2.78 5.5599999 8.3400002"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
||||||
|
id="tspan61378">bead</tspan></text>
|
||||||
|
</g>
|
||||||
|
<g
|
||||||
|
id="g61382" />
|
||||||
|
<g
|
||||||
|
id="g61384" />
|
||||||
|
<g
|
||||||
|
id="g61386" />
|
||||||
|
<g
|
||||||
|
id="g61388" />
|
||||||
|
<g
|
||||||
|
id="g61390" />
|
||||||
|
<g
|
||||||
|
id="g61392" />
|
||||||
|
<g
|
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|
id="g61394" />
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||||||
|
<g
|
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|
id="g61396">
|
||||||
|
<text
|
||||||
|
transform="matrix(0,1,1,0,9.79,7.55)"
|
||||||
|
style="font-variant:normal;font-weight:normal;font-size:6px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#000000;fill-opacity:1;fill-rule:nonzero;stroke:none"
|
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|
id="text61400"><tspan
|
||||||
|
x="0 4.3319998 8.6639996 12 15.336 18.672001 22.176001 26.507999 30.84 35.172001 38.507999 42.012001 43.68 47.382 50.717999 52.716 55.716 57.383999 59.051998 61.049999 64.386002 66.054001 67.722 72.054001 76.386002 79.722 83.225998"
|
||||||
|
y="0"
|
||||||
|
sodipodi:role="line"
|
||||||
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id="tspan61398">CD62L+CCR7+ Perc. (of CD3+)</tspan></text>
|
||||||
|
</g>
|
||||||
|
<g
|
||||||
|
id="g61402" />
|
||||||
|
<g
|
||||||
|
id="g61404" />
|
||||||
|
<g
|
||||||
|
id="g61406" />
|
||||||
|
<g
|
||||||
|
id="g61408" />
|
||||||
|
<g
|
||||||
|
id="g61410" />
|
||||||
|
<g
|
||||||
|
id="g61412" />
|
||||||
|
<g
|
||||||
|
id="g61414" />
|
||||||
|
<g
|
||||||
|
id="g61416" />
|
||||||
|
<g
|
||||||
|
id="g61418" />
|
||||||
|
<g
|
||||||
|
id="g61420" />
|
||||||
|
<g
|
||||||
|
id="g61422" />
|
||||||
|
<g
|
||||||
|
id="g61424" />
|
||||||
|
</g>
|
||||||
</g>
|
</g>
|
||||||
</svg>
|
</svg>
|
||||||
|
|
|
||||||
|
Before Width: | Height: | Size: 92 KiB After Width: | Height: | Size: 69 KiB |
|
|
@ -1631,6 +1631,7 @@ for bead (\cref{fig:car_bcma_total}).
|
||||||
|
|
||||||
\subsection{DMSs efficiently expand T cells in Grex bioreactors}
|
\subsection{DMSs efficiently expand T cells in Grex bioreactors}
|
||||||
|
|
||||||
|
% RESULT update this in light of the grex data
|
||||||
We also asked if the \gls{dms} platform could expand T cells in a static
|
We also asked if the \gls{dms} platform could expand T cells in a static
|
||||||
bioreactor such a Grex. We incubated T cells in a Grex analogously to that for
|
bioreactor such a Grex. We incubated T cells in a Grex analogously to that for
|
||||||
plates and found that T cells in Grex bioreactors expanded as efficiently as
|
plates and found that T cells in Grex bioreactors expanded as efficiently as
|
||||||
|
|
@ -1651,9 +1652,6 @@ area could mean higher signaling and higher differentiation rate to effector T
|
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cells, which was why the \ptmemp{} was so low compared to other data
|
cells, which was why the \ptmemp{} was so low compared to other data
|
||||||
(\cref{fig:dms_phenotype_mem}).
|
(\cref{fig:dms_phenotype_mem}).
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||||||
|
|
||||||
% TODO this figure has wonky proportions
|
|
||||||
% TODO add stats for the phenotype stuff
|
|
||||||
% TODO the phenotype figure should say "percent of CD3+"
|
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\begin{figure*}[ht!]
|
\begin{figure*}[ht!]
|
||||||
\begingroup
|
\begingroup
|
||||||
|
|
||||||
|
|
|
||||||
Loading…
Reference in New Issue