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ENH integrate expansion figure

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Nathan Dwarshuis 2021-07-23 17:34:04 -04:00
parent 03907accdc
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tex/thesis.tex
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@ -123,6 +123,10 @@
\newcommand{\cdp}[1]{\pos{\cd{#1}}}
\newcommand{\cdn}[1]{\cd{#1}-}
\newcommand{\ptmem}{\cdp{62L}\pos{CCR7}}
\newcommand{\pth}{\cdp{4}}
\newcommand{\ptk}{\cdp{8}}
\newcommand{\ptmemh}{\pth\ptmem}
\newcommand{\ptmemk}{\ptk\ptmem}
\newcommand{\catnum}[2]{(#1, #2)}
\newcommand{\product}[3]{#1 \catnum{#2}{#3}}
@ -977,7 +981,7 @@ context of pure error). Statistical significance was evaluated at $\upalpha$ =
\phantomsubcaption\label{fig:dms_cells_fluor}
\endgroup
\caption[\gls{dms} Reaction timing]
\caption[T cells growing on \glspl{dms}]
{Cells grow in tight clusters in and around functionalized \gls{dms}.
\subcap{fig:dms_cells_phase}{Phase-contrast image of T cells growing on
\glspl{dms} on day 7}
@ -985,14 +989,41 @@ context of pure error). Statistical significance was evaluated at $\upalpha$ =
growing on \glspl{dms} on day 9. \Glspl{dms} were stained using
\gls{stppe} (red) and T cells were stained using \acd{45}-\gls{af647}.}
}
\label{fig:dms_flowchart}
\label{fig:dms_cells}
\end{figure*}
% 3-donor expansion figure
\subsection{DMSs lead to greater expansion and memory and CD4+ phenotypes}
% phenotype expansion plots
% TODO add significance tests to this
\begin{figure*}[ht!]
\begingroup
\includegraphics{../figures/dms_vs_bead_expansion.png}
\phantomsubcaption\label{fig:dms_exp_fold_change}
\phantomsubcaption\label{fig:dms_exp_mem}
\phantomsubcaption\label{fig:dms_exp_cd4}
\phantomsubcaption\label{fig:dms_exp_mem4}
\phantomsubcaption\label{fig:dms_exp_mem8}
\endgroup
\caption[\gls{dms} vs bead expansion]
{\gls{dms} lead to superior expansion of T cells compared to beads across
multiple donors.
\subcap{fig:dms_exp_fold_change}{Longitudinal fold change of T cells grown
using either \glspl{dms} or beads. Significance was evaulated using t
tests at each timepoint}
Fold change of subpopulations expanded using either \gls{dms} or beads at
day 14, including
\subcap{fig:dms_exp_mem}{\ptmem{} cells},
\subcap{fig:dms_exp_cd4}{\pth{} cells},
\subcap{fig:dms_exp_mem4}{\ptmemh{} cells}, and
\subcap{fig:dms_exp_mem8}{\ptmemk{} cells}
}
\label{fig:dms_exp}
\end{figure*}
% phenotype flow plots
\subsection*{DMSs can be used to produce functional CAR T cells}