ADD experimental overview and fold change/viability plots to il15 data
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@ -3033,27 +3033,31 @@ many conditions, we hypothesized that \gls{il15} may be responsible for this,
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and further that the unique \textit{cis/trans} activity of \gls{il15} may be
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more active in the \gls{dms} system due to higher cell density.
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% TODO actually add captions
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% TODO add fold change and viability to these
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% TODO maybe combine these
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% TODO add some background into why IL15 is important and the proposed mechanism
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\begin{figure*}[ht!]
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\begingroup
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\includegraphics{../figures/il15_blockade_1.png}
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\phantomsubcaption\label{fig:il15_1_overview}
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\phantomsubcaption\label{fig:il15_1_fc}
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\phantomsubcaption\label{fig:il15_1_viability}
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\phantomsubcaption\label{fig:il15_1_mem}
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\endgroup
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\caption[IL15 blocking I]
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{Blocking with IL15 does not lead to differences in memory or growth.
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{Blocking IL15Ra does not lead to differences in memory or growth.
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\subcap{fig:il15_1_overview}{Experimental overview}
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Longitudinal measurements of
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\subcap{fig:il15_1_fc}{fold change} and
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\subcap{fig:il15_1_viability}{viability} for blocked and unblocked
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conditions expanded with either beads or \glspl{dms}.
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\subcap{fig:il15_1_mem}{Flow cytometry markers for \gls{dms}-expanded T
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cells at day 14 for blocked and unblocked groups.}.
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}
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\label{fig:il15_1}
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\end{figure*}
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% TODO how did I determine how much to add?
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% TODO how often was this added?
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% TODO just gate these as normal because this looks sketchy
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We first tested this hypothesis by blocking \gls{il15r} with either a specific
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\gls{mab} or an \gls{igg} isotype control. We observed no difference in the
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@ -3070,13 +3074,21 @@ the markers, and by extension showing no difference in phenotype
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\begingroup
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\includegraphics{../figures/il15_blockade_2.png}
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\phantomsubcaption\label{fig:il15_2_overview}
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\phantomsubcaption\label{fig:il15_2_fc}
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\phantomsubcaption\label{fig:il15_2_viability}
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\phantomsubcaption\label{fig:il15_2_mem}
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\endgroup
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\caption[IL15 blocking II]
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{Blocking with IL15 does not lead to differences in memory or growth.
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{Blocking soluble IL15 does not lead to differences in memory or growth.
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\subcap{fig:il15_2_overview}{Experimental overview}
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Longitudinal measurements of
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\subcap{fig:il15_2_fc}{fold change} and
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\subcap{fig:il15_2_viability}{viability} for blocked and unblocked
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conditions expanded with \glspl{dms}.
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\subcap{fig:il15_2_mem}{Flow cytometry markers for \gls{dms}-expanded T
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cells at day 14 for blocked and unblocked groups.}.
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}
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\label{fig:il15_2}
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\end{figure*}
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