ADD figs/tables for aim 3

This commit is contained in:
Nathan Dwarshuis 2021-07-26 13:24:31 -04:00
parent 5b6c4bed54
commit ddb623424e
8 changed files with 13548 additions and 0 deletions

File diff suppressed because it is too large Load Diff

After

Width:  |  Height:  |  Size: 61 KiB

File diff suppressed because one or more lines are too long

After

Width:  |  Height:  |  Size: 3.2 MiB

View File

@ -0,0 +1,534 @@
<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<!-- Created with Inkscape (http://www.inkscape.org/) -->
<svg
width="6in"
height="9in"
viewBox="0 0 576.00003 864.00004"
version="1.1"
id="svg8"
inkscape:version="1.1 (c4e8f9ed74, 2021-05-24)"
sodipodi:docname="mouse_dosing_overview.svg"
xmlns:inkscape="http://www.inkscape.org/namespaces/inkscape"
xmlns:sodipodi="http://sodipodi.sourceforge.net/DTD/sodipodi-0.dtd"
xmlns="http://www.w3.org/2000/svg"
xmlns:svg="http://www.w3.org/2000/svg"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cc="http://creativecommons.org/ns#"
xmlns:dc="http://purl.org/dc/elements/1.1/">
<defs
id="defs2">
<marker
style="overflow:visible;"
id="Arrow2Mend"
refX="0.0"
refY="0.0"
orient="auto"
inkscape:stockid="Arrow2Mend"
inkscape:isstock="true">
<path
transform="scale(0.6) rotate(180) translate(0,0)"
d="M 8.7185878,4.0337352 L -2.2072895,0.016013256 L 8.7185884,-4.0017078 C 6.9730900,-1.6296469 6.9831476,1.6157441 8.7185878,4.0337352 z "
style="fill-rule:evenodd;fill:context-stroke;stroke-width:0.62500000;stroke-linejoin:round;"
id="path103030" />
</marker>
<clipPath
id="clip8">
<path
id="path1000"
d="M 45.472656,24 H 553.76172 v 2 H 45.472656 Z m 0,0" />
</clipPath>
<clipPath
id="clip10">
<path
id="path1006"
d="m 553,17 h 0.76172 V 40 H 553 Z m 0,0" />
</clipPath>
<clipPath
id="clip8-3">
<path
id="path1000-6"
d="M 45.472656,24 H 553.76172 v 2 H 45.472656 Z m 0,0" />
</clipPath>
<clipPath
id="clip10-7">
<path
id="path1006-5"
d="m 553,17 h 0.76172 V 40 H 553 Z m 0,0" />
</clipPath>
<marker
style="overflow:visible"
id="Arrow2Mend-6"
refX="0"
refY="0"
orient="auto"
inkscape:stockid="Arrow2Mend"
inkscape:isstock="true">
<path
transform="scale(-0.6)"
d="M 8.7185878,4.0337352 -2.2072895,0.01601326 8.7185884,-4.0017078 c -1.7454984,2.3720609 -1.7354408,5.6174519 -6e-7,8.035443 z"
style="fill:context-stroke;fill-rule:evenodd;stroke-width:0.625;stroke-linejoin:round"
id="path103030-1" />
</marker>
<marker
style="overflow:visible"
id="Arrow2Mend-6-6"
refX="0"
refY="0"
orient="auto"
inkscape:stockid="Arrow2Mend"
inkscape:isstock="true">
<path
transform="scale(-0.6)"
d="M 8.7185878,4.0337352 -2.2072895,0.01601326 8.7185884,-4.0017078 c -1.7454984,2.3720609 -1.7354408,5.6174519 -6e-7,8.035443 z"
style="fill:context-stroke;fill-rule:evenodd;stroke-width:0.625;stroke-linejoin:round"
id="path103030-1-3" />
</marker>
</defs>
<sodipodi:namedview
id="base"
pagecolor="#ffffff"
bordercolor="#666666"
borderopacity="1.0"
inkscape:pageopacity="1"
inkscape:pageshadow="2"
inkscape:zoom="2.8"
inkscape:cx="175.71429"
inkscape:cy="148.75"
inkscape:document-units="px"
inkscape:current-layer="layer1"
showgrid="true"
units="in"
inkscape:window-width="1920"
inkscape:window-height="1036"
inkscape:window-x="1920"
inkscape:window-y="20"
inkscape:window-maximized="0"
inkscape:pagecheckerboard="0"
inkscape:snap-grids="false">
<inkscape:grid
type="xygrid"
id="grid11039"
units="in"
spacingx="12.000001"
spacingy="12.000001"
color="#9f9f9f"
opacity="0.1254902" />
</sodipodi:namedview>
<metadata
id="metadata5">
<rdf:RDF>
<cc:Work
rdf:about="">
<dc:format>image/svg+xml</dc:format>
<dc:type
rdf:resource="http://purl.org/dc/dcmitype/StillImage" />
</cc:Work>
</rdf:RDF>
</metadata>
<g
inkscape:label="Layer 1"
inkscape:groupmode="layer"
id="layer1">
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1344"
transform="matrix(1.3333334,0,0,1.3333334,-26.75734,146.60243)">
<g
id="use1340"
transform="translate(42.956753,14.745141)">
<path
id="path65650"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1342"
transform="translate(47.085396,14.745141)">
<path
id="path65670"
d="m 0.25,-2.125 c 0,-0.5 0.050781,-0.90625 0.15625,-1.21875 0.101562,-0.3125 0.257812,-0.550781 0.46875,-0.71875 0.207031,-0.164062 0.46875,-0.25 0.78125,-0.25 0.226562,0 0.425781,0.046875 0.59375,0.140625 0.175781,0.09375 0.320312,0.230469 0.4375,0.40625 0.113281,0.167969 0.203125,0.382813 0.265625,0.640625 0.0625,0.25 0.09375,0.585938 0.09375,1 0,0.511719 -0.054687,0.921875 -0.15625,1.234375 -0.105469,0.304687 -0.261719,0.542969 -0.46875,0.71875 -0.199219,0.16796875 -0.453125,0.25 -0.765625,0.25 -0.417969,0 -0.746094,-0.1484375 -0.984375,-0.453125 C 0.390625,-0.726562 0.25,-1.3125 0.25,-2.125 Z m 0.546875,0 c 0,0.710938 0.078125,1.183594 0.234375,1.421875 0.164062,0.230469 0.375,0.34375 0.625,0.34375 0.238281,0 0.441406,-0.113281 0.609375,-0.34375 0.164063,-0.238281 0.25,-0.710937 0.25,-1.421875 0,-0.695312 -0.085937,-1.160156 -0.25,-1.390625 -0.167969,-0.238281 -0.375,-0.359375 -0.625,-0.359375 -0.242187,0 -0.433594,0.105469 -0.578125,0.3125 -0.179688,0.261719 -0.265625,0.742188 -0.265625,1.4375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1350"
transform="matrix(1.3333334,0,0,1.3333334,-39.46848,146.60243)">
<g
id="use1346"
transform="translate(119.55963,14.9849)">
<path
id="path65654"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1348"
transform="translate(123.68828,14.9849)">
<path
id="path65646"
d="M 2.984375,-3.25 2.46875,-3.203125 C 2.414062,-3.410156 2.347656,-3.5625 2.265625,-3.65625 2.117188,-3.800781 1.941406,-3.875 1.734375,-3.875 c -0.167969,0 -0.3125,0.046875 -0.4375,0.140625 -0.167969,0.117187 -0.304687,0.292969 -0.40625,0.53125 C 0.796875,-2.972656 0.75,-2.644531 0.75,-2.21875 c 0.125,-0.1875 0.273438,-0.328125 0.453125,-0.421875 0.1875,-0.09375 0.382813,-0.140625 0.59375,-0.140625 0.351563,0 0.648437,0.132812 0.890625,0.390625 0.25,0.25 0.375,0.585937 0.375,1 0,0.273437 -0.058594,0.523437 -0.171875,0.75 -0.117187,0.230469 -0.277344,0.40625 -0.484375,0.53125 -0.199219,0.125 -0.429688,0.1875 -0.6875,0.1875 -0.4375,0 -0.796875,-0.1601562 -1.078125,-0.484375 -0.28125,-0.320312 -0.421875,-0.859375 -0.421875,-1.609375 0,-0.820313 0.15625,-1.425781 0.46875,-1.8125 0.269531,-0.320313 0.628906,-0.484375 1.078125,-0.484375 0.34375,0 0.617187,0.09375 0.828125,0.28125 0.21875,0.1875 0.347656,0.449219 0.390625,0.78125 z m -2.15625,1.859375 c 0,0.179687 0.035156,0.351563 0.109375,0.515625 0.082031,0.167969 0.191406,0.296875 0.328125,0.390625 0.144531,0.085937 0.289063,0.125 0.4375,0.125 0.226563,0 0.421875,-0.085937 0.578125,-0.265625 C 2.4375,-0.8125 2.515625,-1.054688 2.515625,-1.359375 2.515625,-1.660156 2.4375,-1.894531 2.28125,-2.0625 2.125,-2.238281 1.925781,-2.328125 1.6875,-2.328125 c -0.242188,0 -0.445312,0.089844 -0.609375,0.265625 -0.167969,0.167969 -0.25,0.390625 -0.25,0.671875 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1356"
transform="matrix(1.3333334,0,0,1.3333334,-37.3825,146.60243)">
<g
id="use1352"
transform="translate(183.93483,14.025865)">
<path
id="path65658"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1354"
transform="translate(188.06348,14.025865)">
<path
id="path65678"
d="m 0.28125,-3.734375 v -0.5 H 3.0625 v 0.40625 C 2.789062,-3.535156 2.519531,-3.148438 2.25,-2.671875 1.976562,-2.191406 1.769531,-1.695312 1.625,-1.1875 1.519531,-0.820312 1.453125,-0.425781 1.421875,0 h -0.53125 c 0,-0.332031 0.0625,-0.738281 0.1875,-1.21875 0.132813,-0.476562 0.316406,-0.941406 0.546875,-1.390625 0.238281,-0.445313 0.492188,-0.820313 0.765625,-1.125 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1364"
transform="matrix(1.3333334,0,0,1.3333334,-87.08491,146.60243)">
<g
id="use1358"
transform="translate(293.50452,16.063814)">
<path
id="path65662"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1360"
transform="translate(297.63318,16.063814)">
<path
id="path65642"
d="m 2.234375,0 h -0.53125 v -3.359375 c -0.125,0.125 -0.292969,0.25 -0.5,0.375 C 1.003906,-2.867188 0.820312,-2.78125 0.65625,-2.71875 v -0.515625 c 0.289062,-0.132813 0.546875,-0.300781 0.765625,-0.5 C 1.648438,-3.929688 1.804688,-4.125 1.890625,-4.3125 h 0.34375 z m 0,0"
style="stroke:none" />
</g>
<g
id="use1362"
transform="translate(300.76682,16.063814)">
<path
id="path65634"
d="M 1.9375,0 V -1.03125 H 0.078125 v -0.484375 l 1.953125,-2.78125 h 0.4375 v 2.78125 H 3.046875 V -1.03125 H 2.46875 V 0 Z m 0,-1.515625 v -1.9375 l -1.34375,1.9375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g2192"
transform="matrix(1.3333334,0,0,1.3333334,-184.20857,146.60243)">
<g
id="use2186"
transform="translate(545.97034,15.464417)">
<path
id="path65666"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use2188"
transform="translate(550.099,15.464417)">
<path
id="path65638"
d="M 1.9375,0 V -1.03125 H 0.078125 v -0.484375 l 1.953125,-2.78125 h 0.4375 v 2.78125 H 3.046875 V -1.03125 H 2.46875 V 0 Z m 0,-1.515625 v -1.9375 l -1.34375,1.9375 z m 0,0"
style="stroke:none" />
</g>
<g
id="use2190"
transform="translate(553.23267,15.464417)">
<path
id="path65674"
d="m 0.25,-2.125 c 0,-0.5 0.050781,-0.90625 0.15625,-1.21875 0.101562,-0.3125 0.257812,-0.550781 0.46875,-0.71875 0.207031,-0.164062 0.46875,-0.25 0.78125,-0.25 0.226562,0 0.425781,0.046875 0.59375,0.140625 0.175781,0.09375 0.320312,0.230469 0.4375,0.40625 0.113281,0.167969 0.203125,0.382813 0.265625,0.640625 0.0625,0.25 0.09375,0.585938 0.09375,1 0,0.511719 -0.054687,0.921875 -0.15625,1.234375 -0.105469,0.304687 -0.261719,0.542969 -0.46875,0.71875 -0.199219,0.16796875 -0.453125,0.25 -0.765625,0.25 -0.417969,0 -0.746094,-0.1484375 -0.984375,-0.453125 C 0.390625,-0.726562 0.25,-1.3125 0.25,-2.125 Z m 0.546875,0 c 0,0.710938 0.078125,1.183594 0.234375,1.421875 0.164062,0.230469 0.375,0.34375 0.625,0.34375 0.238281,0 0.441406,-0.113281 0.609375,-0.34375 0.164063,-0.238281 0.25,-0.710937 0.25,-1.421875 0,-0.695312 -0.085937,-1.160156 -0.25,-1.390625 -0.167969,-0.238281 -0.375,-0.359375 -0.625,-0.359375 -0.242187,0 -0.433594,0.105469 -0.578125,0.3125 -0.179688,0.261719 -0.265625,0.742188 -0.265625,1.4375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="clip-rule:nonzero"
clip-path="url(#clip8)"
id="g2218"
transform="matrix(1.3333334,0,0,1.3333334,-25.56548,148.27065)">
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:12700;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M -9.992266,6.827687 H 6701740.2"
transform="matrix(5.76696e-5,0,0,5.76696e-5,45.84042,25.2457)"
id="path2216"
sodipodi:nodetypes="cc" />
</g>
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="m 125.05097,170.68189 v 24.16533"
id="path2224" />
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="m 212.97055,170.68189 v 24.16533"
id="path2226" />
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="m 311.43974,170.68189 v 24.16533"
id="path2228" />
<g
style="clip-rule:nonzero;stroke-width:1.08317"
clip-path="url(#clip10)"
id="g2232"
transform="matrix(1.3331734,0,0,1.1365654,-186.81542,149.48006)">
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:13756.3;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M -30.670405,3.034528 V 368684.61"
transform="matrix(5.76696e-5,0,0,5.76696e-5,553.3963,17.9217)"
id="path2230" />
</g>
<text
xml:space="preserve"
style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
x="452.52307"
y="206.04544"
id="text32088"><tspan
sodipodi:role="line"
id="tspan32086"
x="452.52307"
y="206.04544"
style="font-size:8px;text-align:center;text-anchor:middle">Bioluminescence imaging at 5-7 day</tspan><tspan
sodipodi:role="line"
x="452.52307"
y="216.04544"
id="tspan32120"
style="font-size:8px;text-align:center;text-anchor:middle">intervals and survival monitoring</tspan></text>
<text
xml:space="preserve"
style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
x="35.392853"
y="206.04544"
id="text32092"><tspan
sodipodi:role="line"
id="tspan32090"
x="35.392853"
y="206.04544"
style="font-size:8px;text-align:center;text-anchor:middle">Nalm-6-ffluc</tspan><tspan
sodipodi:role="line"
x="35.392853"
y="216.04544"
id="tspan32094"
style="font-size:8px;text-align:center;text-anchor:middle">tumor cell</tspan><tspan
sodipodi:role="line"
x="35.392853"
y="226.04544"
id="tspan32096"
style="font-size:8px;text-align:center;text-anchor:middle">injection (1e6, IV)</tspan></text>
<text
xml:space="preserve"
style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
x="124.85381"
y="206.04544"
id="text32100"><tspan
sodipodi:role="line"
id="tspan32098"
x="124.85381"
y="206.04544"
style="font-size:8px;text-align:center;text-anchor:middle">Bioluminescence</tspan><tspan
sodipodi:role="line"
x="124.85381"
y="216.04544"
id="tspan32102"
style="font-size:8px;text-align:center;text-anchor:middle">imaging</tspan></text>
<text
xml:space="preserve"
style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
x="213.05695"
y="206.04544"
id="text32106"><tspan
sodipodi:role="line"
x="213.05695"
y="206.04544"
id="tspan32108"
style="font-size:8px;text-align:center;text-anchor:middle">CAR T cell injection</tspan><tspan
sodipodi:role="line"
x="213.05695"
y="216.04544"
id="tspan32112"
style="font-size:8px;text-align:center;text-anchor:middle">(varying doses, IV)</tspan></text>
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="m 35.61451,169.84944 v 24.16533"
id="path2224-3" />
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1344-3"
transform="matrix(1.3333334,0,0,1.3333334,-27.363484,29.24875)">
<g
id="use1340-5"
transform="translate(42.956753,14.745141)">
<path
id="path65650-6"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1342-2"
transform="translate(47.085396,14.745141)">
<path
id="path65670-9"
d="m 0.25,-2.125 c 0,-0.5 0.050781,-0.90625 0.15625,-1.21875 0.101562,-0.3125 0.257812,-0.550781 0.46875,-0.71875 0.207031,-0.164062 0.46875,-0.25 0.78125,-0.25 0.226562,0 0.425781,0.046875 0.59375,0.140625 0.175781,0.09375 0.320312,0.230469 0.4375,0.40625 0.113281,0.167969 0.203125,0.382813 0.265625,0.640625 0.0625,0.25 0.09375,0.585938 0.09375,1 0,0.511719 -0.054687,0.921875 -0.15625,1.234375 -0.105469,0.304687 -0.261719,0.542969 -0.46875,0.71875 -0.199219,0.16796875 -0.453125,0.25 -0.765625,0.25 -0.417969,0 -0.746094,-0.1484375 -0.984375,-0.453125 C 0.390625,-0.726562 0.25,-1.3125 0.25,-2.125 Z m 0.546875,0 c 0,0.710938 0.078125,1.183594 0.234375,1.421875 0.164062,0.230469 0.375,0.34375 0.625,0.34375 0.238281,0 0.441406,-0.113281 0.609375,-0.34375 0.164063,-0.238281 0.25,-0.710937 0.25,-1.421875 0,-0.695312 -0.085937,-1.160156 -0.25,-1.390625 -0.167969,-0.238281 -0.375,-0.359375 -0.625,-0.359375 -0.242187,0 -0.433594,0.105469 -0.578125,0.3125 -0.179688,0.261719 -0.265625,0.742188 -0.265625,1.4375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1364-6"
transform="matrix(1.3333334,0,0,1.3333334,-87.691054,29.24875)">
<g
id="use1358-1"
transform="translate(293.50452,16.063814)">
<path
id="path65662-8"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1360-7"
transform="translate(297.63318,16.063814)">
<path
id="path65642-9"
d="m 2.234375,0 h -0.53125 v -3.359375 c -0.125,0.125 -0.292969,0.25 -0.5,0.375 C 1.003906,-2.867188 0.820312,-2.78125 0.65625,-2.71875 v -0.515625 c 0.289062,-0.132813 0.546875,-0.300781 0.765625,-0.5 C 1.648438,-3.929688 1.804688,-4.125 1.890625,-4.3125 h 0.34375 z m 0,0"
style="stroke:none" />
</g>
<g
id="use1362-2"
transform="translate(300.76682,16.063814)">
<path
id="path65634-0"
d="M 1.9375,0 V -1.03125 H 0.078125 v -0.484375 l 1.953125,-2.78125 h 0.4375 v 2.78125 H 3.046875 V -1.03125 H 2.46875 V 0 Z m 0,-1.515625 v -1.9375 l -1.34375,1.9375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="clip-rule:nonzero"
clip-path="url(#clip8-3)"
id="g2218-8"
transform="matrix(1.3333334,0,0,1.3333334,-26.171624,30.91697)">
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:12700;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M -9.992266,6.827687 H 3581623.1"
transform="matrix(5.76696e-5,0,0,5.76696e-5,45.84042,25.2457)"
id="path2216-9"
sodipodi:nodetypes="cc" />
</g>
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M 96.44483,53.32821 V 77.49354"
id="path2224-7" />
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M 310.8336,53.32821 V 77.49354"
id="path2228-6" />
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M 35.008366,52.49576 V 76.66109"
id="path2224-3-9" />
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="35.008366"
y="85.102524"
id="text84874"><tspan
sodipodi:role="line"
id="tspan84872"
x="35.008366"
y="85.102524"
style="text-align:center;text-anchor:middle">Activate</tspan><tspan
sodipodi:role="line"
x="35.008366"
y="95.102524"
id="tspan167694"
style="text-align:center;text-anchor:middle">(bead or DMS)</tspan></text>
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="76.364754"
y="89.102524"
id="text86396"><tspan
sodipodi:role="line"
id="tspan86394"
x="76.364754"
y="89.102524">Transduce</tspan></text>
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="287.78479"
y="88.184555"
id="text89754"><tspan
sodipodi:role="line"
id="tspan89752"
x="287.78479"
y="88.184555">Harvest/QC</tspan></text>
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="90.796394"
y="49.013107"
id="text100374"><tspan
sodipodi:role="line"
id="tspan100372"
x="90.796394"
y="49.013107">D1</tspan></text>
<path
style="fill:none;stroke:#ff0000;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;marker-end:url(#Arrow2Mend)"
d="m 310.24978,94.000008 v 35.943402 l -97.56069,0.0566 v 24"
id="path102106"
sodipodi:nodetypes="cccc" />
<text
xml:space="preserve"
style="font-size:16px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="12.360558"
y="24.305531"
id="text111838"><tspan
sodipodi:role="line"
id="tspan111836"
x="12.360558"
y="24.305531">T cell expansion</tspan></text>
<text
xml:space="preserve"
style="font-size:16px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="12.360558"
y="135.38815"
id="text114218"><tspan
sodipodi:role="line"
id="tspan114216"
x="12.360558"
y="135.38815">NSG Mice</tspan></text>
<text
xml:space="preserve"
style="font-size:10.6667px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="384.12033"
y="107.6088"
id="text138285"><tspan
sodipodi:role="line"
x="384.12033"
y="107.6088"
id="tspan139367"
style="text-align:center;text-anchor:middle;fill:#ff0000;fill-opacity:1">Test T cells at</tspan><tspan
sodipodi:role="line"
x="384.12033"
y="120.94217"
style="text-align:center;text-anchor:middle;fill:#ff0000;fill-opacity:1"
id="tspan164127">varying doses</tspan></text>
</g>
</svg>

After

Width:  |  Height:  |  Size: 30 KiB

File diff suppressed because it is too large Load Diff

After

Width:  |  Height:  |  Size: 79 KiB

File diff suppressed because one or more lines are too long

After

Width:  |  Height:  |  Size: 11 MiB

View File

@ -0,0 +1,599 @@
<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<!-- Created with Inkscape (http://www.inkscape.org/) -->
<svg
width="6in"
height="9in"
viewBox="0 0 576.00003 864.00004"
version="1.1"
id="svg8"
inkscape:version="1.1 (c4e8f9ed74, 2021-05-24)"
sodipodi:docname="mouse_timecourse_overview.svg"
xmlns:inkscape="http://www.inkscape.org/namespaces/inkscape"
xmlns:sodipodi="http://sodipodi.sourceforge.net/DTD/sodipodi-0.dtd"
xmlns="http://www.w3.org/2000/svg"
xmlns:svg="http://www.w3.org/2000/svg"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cc="http://creativecommons.org/ns#"
xmlns:dc="http://purl.org/dc/elements/1.1/">
<defs
id="defs2">
<marker
style="overflow:visible;"
id="Arrow2Mend"
refX="0.0"
refY="0.0"
orient="auto"
inkscape:stockid="Arrow2Mend"
inkscape:isstock="true">
<path
transform="scale(0.6) rotate(180) translate(0,0)"
d="M 8.7185878,4.0337352 L -2.2072895,0.016013256 L 8.7185884,-4.0017078 C 6.9730900,-1.6296469 6.9831476,1.6157441 8.7185878,4.0337352 z "
style="fill-rule:evenodd;fill:context-stroke;stroke-width:0.62500000;stroke-linejoin:round;"
id="path103030" />
</marker>
<clipPath
id="clip8">
<path
id="path1000"
d="M 45.472656,24 H 553.76172 v 2 H 45.472656 Z m 0,0" />
</clipPath>
<clipPath
id="clip10">
<path
id="path1006"
d="m 553,17 h 0.76172 V 40 H 553 Z m 0,0" />
</clipPath>
<clipPath
id="clip8-3">
<path
id="path1000-6"
d="M 45.472656,24 H 553.76172 v 2 H 45.472656 Z m 0,0" />
</clipPath>
<clipPath
id="clip10-7">
<path
id="path1006-5"
d="m 553,17 h 0.76172 V 40 H 553 Z m 0,0" />
</clipPath>
<marker
style="overflow:visible"
id="Arrow2Mend-6"
refX="0"
refY="0"
orient="auto"
inkscape:stockid="Arrow2Mend"
inkscape:isstock="true">
<path
transform="scale(-0.6)"
d="M 8.7185878,4.0337352 -2.2072895,0.01601326 8.7185884,-4.0017078 c -1.7454984,2.3720609 -1.7354408,5.6174519 -6e-7,8.035443 z"
style="fill:context-stroke;fill-rule:evenodd;stroke-width:0.625;stroke-linejoin:round"
id="path103030-1" />
</marker>
<marker
style="overflow:visible"
id="Arrow2Mend-6-6"
refX="0"
refY="0"
orient="auto"
inkscape:stockid="Arrow2Mend"
inkscape:isstock="true">
<path
transform="scale(-0.6)"
d="M 8.7185878,4.0337352 -2.2072895,0.01601326 8.7185884,-4.0017078 c -1.7454984,2.3720609 -1.7354408,5.6174519 -6e-7,8.035443 z"
style="fill:context-stroke;fill-rule:evenodd;stroke-width:0.625;stroke-linejoin:round"
id="path103030-1-3" />
</marker>
</defs>
<sodipodi:namedview
id="base"
pagecolor="#ffffff"
bordercolor="#666666"
borderopacity="1.0"
inkscape:pageopacity="1"
inkscape:pageshadow="2"
inkscape:zoom="7.919596"
inkscape:cx="76.329651"
inkscape:cy="90.976863"
inkscape:document-units="px"
inkscape:current-layer="layer1"
showgrid="true"
units="in"
inkscape:window-width="1920"
inkscape:window-height="1036"
inkscape:window-x="1920"
inkscape:window-y="20"
inkscape:window-maximized="0"
inkscape:pagecheckerboard="0"
inkscape:snap-grids="true">
<inkscape:grid
type="xygrid"
id="grid11039"
units="in"
spacingx="12.000001"
spacingy="12.000001"
color="#9f9f9f"
opacity="0.1254902" />
</sodipodi:namedview>
<metadata
id="metadata5">
<rdf:RDF>
<cc:Work
rdf:about="">
<dc:format>image/svg+xml</dc:format>
<dc:type
rdf:resource="http://purl.org/dc/dcmitype/StillImage" />
</cc:Work>
</rdf:RDF>
</metadata>
<g
inkscape:label="Layer 1"
inkscape:groupmode="layer"
id="layer1">
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1344"
transform="matrix(1.3333334,0,0,1.3333334,-26.75734,146.60243)">
<g
id="use1340"
transform="translate(42.956753,14.745141)">
<path
id="path65650"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1342"
transform="translate(47.085396,14.745141)">
<path
id="path65670"
d="m 0.25,-2.125 c 0,-0.5 0.050781,-0.90625 0.15625,-1.21875 0.101562,-0.3125 0.257812,-0.550781 0.46875,-0.71875 0.207031,-0.164062 0.46875,-0.25 0.78125,-0.25 0.226562,0 0.425781,0.046875 0.59375,0.140625 0.175781,0.09375 0.320312,0.230469 0.4375,0.40625 0.113281,0.167969 0.203125,0.382813 0.265625,0.640625 0.0625,0.25 0.09375,0.585938 0.09375,1 0,0.511719 -0.054687,0.921875 -0.15625,1.234375 -0.105469,0.304687 -0.261719,0.542969 -0.46875,0.71875 -0.199219,0.16796875 -0.453125,0.25 -0.765625,0.25 -0.417969,0 -0.746094,-0.1484375 -0.984375,-0.453125 C 0.390625,-0.726562 0.25,-1.3125 0.25,-2.125 Z m 0.546875,0 c 0,0.710938 0.078125,1.183594 0.234375,1.421875 0.164062,0.230469 0.375,0.34375 0.625,0.34375 0.238281,0 0.441406,-0.113281 0.609375,-0.34375 0.164063,-0.238281 0.25,-0.710937 0.25,-1.421875 0,-0.695312 -0.085937,-1.160156 -0.25,-1.390625 -0.167969,-0.238281 -0.375,-0.359375 -0.625,-0.359375 -0.242187,0 -0.433594,0.105469 -0.578125,0.3125 -0.179688,0.261719 -0.265625,0.742188 -0.265625,1.4375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1350"
transform="matrix(1.3333334,0,0,1.3333334,-39.46848,146.60243)">
<g
id="use1346"
transform="translate(119.55963,14.9849)">
<path
id="path65654"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1348"
transform="translate(123.68828,14.9849)">
<path
id="path65646"
d="M 2.984375,-3.25 2.46875,-3.203125 C 2.414062,-3.410156 2.347656,-3.5625 2.265625,-3.65625 2.117188,-3.800781 1.941406,-3.875 1.734375,-3.875 c -0.167969,0 -0.3125,0.046875 -0.4375,0.140625 -0.167969,0.117187 -0.304687,0.292969 -0.40625,0.53125 C 0.796875,-2.972656 0.75,-2.644531 0.75,-2.21875 c 0.125,-0.1875 0.273438,-0.328125 0.453125,-0.421875 0.1875,-0.09375 0.382813,-0.140625 0.59375,-0.140625 0.351563,0 0.648437,0.132812 0.890625,0.390625 0.25,0.25 0.375,0.585937 0.375,1 0,0.273437 -0.058594,0.523437 -0.171875,0.75 -0.117187,0.230469 -0.277344,0.40625 -0.484375,0.53125 -0.199219,0.125 -0.429688,0.1875 -0.6875,0.1875 -0.4375,0 -0.796875,-0.1601562 -1.078125,-0.484375 -0.28125,-0.320312 -0.421875,-0.859375 -0.421875,-1.609375 0,-0.820313 0.15625,-1.425781 0.46875,-1.8125 0.269531,-0.320313 0.628906,-0.484375 1.078125,-0.484375 0.34375,0 0.617187,0.09375 0.828125,0.28125 0.21875,0.1875 0.347656,0.449219 0.390625,0.78125 z m -2.15625,1.859375 c 0,0.179687 0.035156,0.351563 0.109375,0.515625 0.082031,0.167969 0.191406,0.296875 0.328125,0.390625 0.144531,0.085937 0.289063,0.125 0.4375,0.125 0.226563,0 0.421875,-0.085937 0.578125,-0.265625 C 2.4375,-0.8125 2.515625,-1.054688 2.515625,-1.359375 2.515625,-1.660156 2.4375,-1.894531 2.28125,-2.0625 2.125,-2.238281 1.925781,-2.328125 1.6875,-2.328125 c -0.242188,0 -0.445312,0.089844 -0.609375,0.265625 -0.167969,0.167969 -0.25,0.390625 -0.25,0.671875 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1356"
transform="matrix(1.3333334,0,0,1.3333334,-37.3825,146.60243)">
<g
id="use1352"
transform="translate(183.93483,14.025865)">
<path
id="path65658"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1354"
transform="translate(188.06348,14.025865)">
<path
id="path65678"
d="m 0.28125,-3.734375 v -0.5 H 3.0625 v 0.40625 C 2.789062,-3.535156 2.519531,-3.148438 2.25,-2.671875 1.976562,-2.191406 1.769531,-1.695312 1.625,-1.1875 1.519531,-0.820312 1.453125,-0.425781 1.421875,0 h -0.53125 c 0,-0.332031 0.0625,-0.738281 0.1875,-1.21875 0.132813,-0.476562 0.316406,-0.941406 0.546875,-1.390625 0.238281,-0.445313 0.492188,-0.820313 0.765625,-1.125 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1364"
transform="matrix(1.3333334,0,0,1.3333334,-87.08491,146.60243)">
<g
id="use1358"
transform="translate(293.50452,16.063814)">
<path
id="path65662"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1360"
transform="translate(297.63318,16.063814)">
<path
id="path65642"
d="m 2.234375,0 h -0.53125 v -3.359375 c -0.125,0.125 -0.292969,0.25 -0.5,0.375 C 1.003906,-2.867188 0.820312,-2.78125 0.65625,-2.71875 v -0.515625 c 0.289062,-0.132813 0.546875,-0.300781 0.765625,-0.5 C 1.648438,-3.929688 1.804688,-4.125 1.890625,-4.3125 h 0.34375 z m 0,0"
style="stroke:none" />
</g>
<g
id="use1362"
transform="translate(300.76682,16.063814)">
<path
id="path65634"
d="M 1.9375,0 V -1.03125 H 0.078125 v -0.484375 l 1.953125,-2.78125 h 0.4375 v 2.78125 H 3.046875 V -1.03125 H 2.46875 V 0 Z m 0,-1.515625 v -1.9375 l -1.34375,1.9375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g2192"
transform="matrix(1.3333334,0,0,1.3333334,-184.20857,146.60243)">
<g
id="use2186"
transform="translate(545.97034,15.464417)">
<path
id="path65666"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use2188"
transform="translate(550.099,15.464417)">
<path
id="path65638"
d="M 1.9375,0 V -1.03125 H 0.078125 v -0.484375 l 1.953125,-2.78125 h 0.4375 v 2.78125 H 3.046875 V -1.03125 H 2.46875 V 0 Z m 0,-1.515625 v -1.9375 l -1.34375,1.9375 z m 0,0"
style="stroke:none" />
</g>
<g
id="use2190"
transform="translate(553.23267,15.464417)">
<path
id="path65674"
d="m 0.25,-2.125 c 0,-0.5 0.050781,-0.90625 0.15625,-1.21875 0.101562,-0.3125 0.257812,-0.550781 0.46875,-0.71875 0.207031,-0.164062 0.46875,-0.25 0.78125,-0.25 0.226562,0 0.425781,0.046875 0.59375,0.140625 0.175781,0.09375 0.320312,0.230469 0.4375,0.40625 0.113281,0.167969 0.203125,0.382813 0.265625,0.640625 0.0625,0.25 0.09375,0.585938 0.09375,1 0,0.511719 -0.054687,0.921875 -0.15625,1.234375 -0.105469,0.304687 -0.261719,0.542969 -0.46875,0.71875 -0.199219,0.16796875 -0.453125,0.25 -0.765625,0.25 -0.417969,0 -0.746094,-0.1484375 -0.984375,-0.453125 C 0.390625,-0.726562 0.25,-1.3125 0.25,-2.125 Z m 0.546875,0 c 0,0.710938 0.078125,1.183594 0.234375,1.421875 0.164062,0.230469 0.375,0.34375 0.625,0.34375 0.238281,0 0.441406,-0.113281 0.609375,-0.34375 0.164063,-0.238281 0.25,-0.710937 0.25,-1.421875 0,-0.695312 -0.085937,-1.160156 -0.25,-1.390625 -0.167969,-0.238281 -0.375,-0.359375 -0.625,-0.359375 -0.242187,0 -0.433594,0.105469 -0.578125,0.3125 -0.179688,0.261719 -0.265625,0.742188 -0.265625,1.4375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="clip-rule:nonzero"
clip-path="url(#clip8)"
id="g2218"
transform="matrix(1.3333334,0,0,1.3333334,-25.56548,148.27065)">
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:12700;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M -9.992266,6.827687 H 6701740.2"
transform="matrix(5.76696e-5,0,0,5.76696e-5,45.84042,25.2457)"
id="path2216"
sodipodi:nodetypes="cc" />
</g>
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="m 125.05097,170.68189 v 24.16533"
id="path2224" />
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="m 212.97055,170.68189 v 24.16533"
id="path2226" />
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="m 311.43974,170.68189 v 24.16533"
id="path2228" />
<g
style="clip-rule:nonzero;stroke-width:1.08317"
clip-path="url(#clip10)"
id="g2232"
transform="matrix(1.3331734,0,0,1.1365654,-186.81542,149.48006)">
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:13756.3;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M -30.670405,3.034528 V 368684.61"
transform="matrix(5.76696e-5,0,0,5.76696e-5,553.3963,17.9217)"
id="path2230" />
</g>
<text
xml:space="preserve"
style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
x="452.52307"
y="206.04544"
id="text32088"><tspan
sodipodi:role="line"
id="tspan32086"
x="452.52307"
y="206.04544"
style="font-size:8px;text-align:center;text-anchor:middle">Bioluminescence imaging at 5-7 day</tspan><tspan
sodipodi:role="line"
x="452.52307"
y="216.04544"
id="tspan32120"
style="font-size:8px;text-align:center;text-anchor:middle">intervals and survival monitoring</tspan></text>
<text
xml:space="preserve"
style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
x="35.392853"
y="206.04544"
id="text32092"><tspan
sodipodi:role="line"
id="tspan32090"
x="35.392853"
y="206.04544"
style="font-size:8px;text-align:center;text-anchor:middle">Nalm-6-ffluc</tspan><tspan
sodipodi:role="line"
x="35.392853"
y="216.04544"
id="tspan32094"
style="font-size:8px;text-align:center;text-anchor:middle">tumor cell</tspan><tspan
sodipodi:role="line"
x="35.392853"
y="226.04544"
id="tspan32096"
style="font-size:8px;text-align:center;text-anchor:middle">injection (1e6, IV)</tspan></text>
<text
xml:space="preserve"
style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
x="124.85381"
y="206.04544"
id="text32100"><tspan
sodipodi:role="line"
id="tspan32098"
x="124.85381"
y="206.04544"
style="font-size:8px;text-align:center;text-anchor:middle">Bioluminescence</tspan><tspan
sodipodi:role="line"
x="124.85381"
y="216.04544"
id="tspan32102"
style="font-size:8px;text-align:center;text-anchor:middle">imaging</tspan></text>
<text
xml:space="preserve"
style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
x="213.05695"
y="206.04544"
id="text32106"><tspan
sodipodi:role="line"
x="213.05695"
y="206.04544"
id="tspan32112"
style="font-size:8px;text-align:center;text-anchor:middle">CAR T cell injection</tspan></text>
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="m 35.61451,169.84944 v 24.16533"
id="path2224-3" />
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1344-3"
transform="matrix(1.3333334,0,0,1.3333334,-27.363484,29.24875)">
<g
id="use1340-5"
transform="translate(42.956753,14.745141)">
<path
id="path65650-6"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1342-2"
transform="translate(47.085396,14.745141)">
<path
id="path65670-9"
d="m 0.25,-2.125 c 0,-0.5 0.050781,-0.90625 0.15625,-1.21875 0.101562,-0.3125 0.257812,-0.550781 0.46875,-0.71875 0.207031,-0.164062 0.46875,-0.25 0.78125,-0.25 0.226562,0 0.425781,0.046875 0.59375,0.140625 0.175781,0.09375 0.320312,0.230469 0.4375,0.40625 0.113281,0.167969 0.203125,0.382813 0.265625,0.640625 0.0625,0.25 0.09375,0.585938 0.09375,1 0,0.511719 -0.054687,0.921875 -0.15625,1.234375 -0.105469,0.304687 -0.261719,0.542969 -0.46875,0.71875 -0.199219,0.16796875 -0.453125,0.25 -0.765625,0.25 -0.417969,0 -0.746094,-0.1484375 -0.984375,-0.453125 C 0.390625,-0.726562 0.25,-1.3125 0.25,-2.125 Z m 0.546875,0 c 0,0.710938 0.078125,1.183594 0.234375,1.421875 0.164062,0.230469 0.375,0.34375 0.625,0.34375 0.238281,0 0.441406,-0.113281 0.609375,-0.34375 0.164063,-0.238281 0.25,-0.710937 0.25,-1.421875 0,-0.695312 -0.085937,-1.160156 -0.25,-1.390625 -0.167969,-0.238281 -0.375,-0.359375 -0.625,-0.359375 -0.242187,0 -0.433594,0.105469 -0.578125,0.3125 -0.179688,0.261719 -0.265625,0.742188 -0.265625,1.4375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="fill:#000000;fill-opacity:0.8471"
id="g1364-6"
transform="matrix(1.3333334,0,0,1.3333334,-87.691054,29.24875)">
<g
id="use1358-1"
transform="translate(293.50452,16.063814)">
<path
id="path65662-8"
d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
style="stroke:none" />
</g>
<g
id="use1360-7"
transform="translate(297.63318,16.063814)">
<path
id="path65642-9"
d="m 2.234375,0 h -0.53125 v -3.359375 c -0.125,0.125 -0.292969,0.25 -0.5,0.375 C 1.003906,-2.867188 0.820312,-2.78125 0.65625,-2.71875 v -0.515625 c 0.289062,-0.132813 0.546875,-0.300781 0.765625,-0.5 C 1.648438,-3.929688 1.804688,-4.125 1.890625,-4.3125 h 0.34375 z m 0,0"
style="stroke:none" />
</g>
<g
id="use1362-2"
transform="translate(300.76682,16.063814)">
<path
id="path65634-0"
d="M 1.9375,0 V -1.03125 H 0.078125 v -0.484375 l 1.953125,-2.78125 h 0.4375 v 2.78125 H 3.046875 V -1.03125 H 2.46875 V 0 Z m 0,-1.515625 v -1.9375 l -1.34375,1.9375 z m 0,0"
style="stroke:none" />
</g>
</g>
<g
style="clip-rule:nonzero"
clip-path="url(#clip8-3)"
id="g2218-8"
transform="matrix(1.3333334,0,0,1.3333334,-26.171624,30.91697)">
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:12700;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M -9.992266,6.827687 H 3581623.1"
transform="matrix(5.76696e-5,0,0,5.76696e-5,45.84042,25.2457)"
id="path2216-9"
sodipodi:nodetypes="cc" />
</g>
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M 96.44483,53.32821 V 77.49354"
id="path2224-7" />
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M 310.8336,53.32821 V 77.49354"
id="path2228-6" />
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M 35.008366,52.49576 V 76.66109"
id="path2224-3-9" />
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="35.008366"
y="85.631821"
id="text84874"><tspan
sodipodi:role="line"
id="tspan84872"
x="35.008366"
y="85.631821"
style="text-align:center;text-anchor:middle">Activate</tspan><tspan
sodipodi:role="line"
x="35.008366"
y="95.631821"
id="tspan173168"
style="text-align:center;text-anchor:middle">(bead or DMS)</tspan></text>
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="76.364754"
y="89.102524"
id="text86396"><tspan
sodipodi:role="line"
id="tspan86394"
x="76.364754"
y="89.102524">Transduce</tspan></text>
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="287.78479"
y="88.184555"
id="text89754"><tspan
sodipodi:role="line"
id="tspan89752"
x="287.78479"
y="88.184555">Harvest/QC</tspan></text>
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="215.9864"
y="88.184555"
id="text89754-4"><tspan
sodipodi:role="line"
id="tspan89752-5"
x="215.9864"
y="88.184555">Harvest/QC</tspan></text>
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="143.99747"
y="88.184555"
id="text89754-4-0"><tspan
sodipodi:role="line"
id="tspan89752-5-3"
x="143.99747"
y="88.184555">Harvest/QC</tspan></text>
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="90.796394"
y="49.013107"
id="text100374"><tspan
sodipodi:role="line"
id="tspan100372"
x="90.796394"
y="49.013107">D1</tspan></text>
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M 167.04629,53.328212 V 77.49354"
id="path2224-7-3" />
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="161.28067"
y="50.667171"
id="text100374-1"><tspan
sodipodi:role="line"
id="tspan100372-9"
x="161.28067"
y="50.667171">D6</tspan></text>
<path
inkscape:connector-curvature="0"
style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
d="M 239.03524,53.32821 V 77.49354"
id="path2224-7-3-4" />
<text
xml:space="preserve"
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="230.73836"
y="50.667171"
id="text100374-1-7"><tspan
sodipodi:role="line"
id="tspan100372-9-8"
x="230.73836"
y="50.667171">D10</tspan></text>
<path
style="fill:none;stroke:#ff0000;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;marker-end:url(#Arrow2Mend)"
d="m 310.24978,94.000008 v 35.943402 l -88.93619,0.0566 v 24"
id="path102106"
sodipodi:nodetypes="cccc" />
<path
style="fill:none;stroke:#ff0000;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;marker-end:url(#Arrow2Mend-6)"
d="m 239.63153,94.000008 v 23.733222 l -27.07619,0.0566 v 36.21018"
id="path102106-0"
sodipodi:nodetypes="cccc" />
<path
style="fill:none;stroke:#ff0000;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;marker-end:url(#Arrow2Mend-6-6)"
d="m 167.53204,94.000008 v 35.943402 l 36.49167,0.0566 v 24"
id="path102106-0-2"
sodipodi:nodetypes="cccc" />
<text
xml:space="preserve"
style="font-size:16px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="12.360558"
y="24.305531"
id="text111838"><tspan
sodipodi:role="line"
id="tspan111836"
x="12.360558"
y="24.305531">T cell expansion</tspan></text>
<text
xml:space="preserve"
style="font-size:16px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="12.360558"
y="135.38815"
id="text114218"><tspan
sodipodi:role="line"
id="tspan114216"
x="12.360558"
y="135.38815">NSG Mice</tspan></text>
<text
xml:space="preserve"
style="font-size:16px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="384.00003"
y="48.000004"
id="text135039"><tspan
sodipodi:role="line"
x="384.00003"
y="48.000004"
id="tspan135043" /></text>
<text
xml:space="preserve"
style="font-size:10.6667px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
x="395.77725"
y="111.72017"
id="text138285"><tspan
sodipodi:role="line"
id="tspan138283"
x="395.77725"
y="111.72017"
style="text-align:center;text-anchor:middle;fill:#ff0000;fill-opacity:1">Test T cells from</tspan><tspan
sodipodi:role="line"
x="395.77725"
y="125.05354"
id="tspan139367"
style="text-align:center;text-anchor:middle;fill:#ff0000;fill-opacity:1">different timepoints</tspan></text>
</g>
</svg>

After

Width:  |  Height:  |  Size: 32 KiB

10
tables/mouse_dose_car.tex Normal file
View File

@ -0,0 +1,10 @@
\begin{tabular}{lcc}
\\[-1.8ex]\hline
\hline \\[-1.8ex]
\\[-1.8ex] & Dose & 1e6 T cells/mouse & 1e6 CAR T cells/mouse 1e6 (DMS) & CAR T cells/mouse (Bead) \\
\hline \\[-1.8ex]
High & 1.25 & 0.855 & 0.315 \\
Medium & 0.8325 & 0.570 & 0.210 \\
Low & 3.313 & 0.214 & 0.079 \\
\hline \\[-1.8ex]
\end{tabular}

View File

@ -1599,6 +1599,23 @@ analyzed using GraphPad Prism using the Mantel-Cox test to assess significance
between survival groups.
\section{results}
\subsection{DMS-expanded T cells show greater anti-tumor activity \invivo{}
compared to beads}
% figure showing the experimental model and dosing strategy
% table for % CAR+ T cells injected into the mice
% figure for the mem and CAR+ percent injected into the mice
% figure showing IVIS images
% figure showing the surival curves
\subsection{Beads and DMSs perform similarly at earlier timepoints}
% figure showing the experimental model and dosing strategy
% figure for the mem and CAR+ percent injected into the mice
% figure showing IVIS images
% figure showing the photon plots per time
\section{discussion}
\chapter{conclusions and future work}\label{conclusions}