ADD figs/tables for aim 3
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style="font-size:8px;text-align:center;text-anchor:middle">Bioluminescence</tspan><tspan
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style="font-size:8px;text-align:center;text-anchor:middle">intervals and survival monitoring</tspan></text>
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|
<text
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|
xml:space="preserve"
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style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
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id="text32092"><tspan
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id="tspan32090"
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style="font-size:8px;text-align:center;text-anchor:middle">Nalm-6-ffluc</tspan><tspan
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style="font-size:8px;text-align:center;text-anchor:middle">tumor cell</tspan><tspan
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|
style="font-size:8px;text-align:center;text-anchor:middle">injection (1e6, IV)</tspan></text>
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<text
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|
xml:space="preserve"
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style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
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id="text32100"><tspan
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sodipodi:role="line"
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style="font-size:8px;text-align:center;text-anchor:middle">Bioluminescence</tspan><tspan
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sodipodi:role="line"
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y="216.04544"
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id="tspan32102"
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style="font-size:8px;text-align:center;text-anchor:middle">imaging</tspan></text>
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|
<text
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xml:space="preserve"
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style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:8px;line-height:1.25;font-family:arial;-inkscape-font-specification:arial;text-align:start;letter-spacing:0px;word-spacing:0px;text-anchor:start;fill:#000000;fill-opacity:1;stroke:none"
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x="213.05695"
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y="206.04544"
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id="text32106"><tspan
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sodipodi:role="line"
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x="213.05695"
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y="206.04544"
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id="tspan32112"
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style="font-size:8px;text-align:center;text-anchor:middle">CAR T cell injection</tspan></text>
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d="m 35.61451,169.84944 v 24.16533"
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id="path2224-3" />
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<g
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style="fill:#000000;fill-opacity:0.8471"
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id="g1344-3"
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transform="matrix(1.3333334,0,0,1.3333334,-27.363484,29.24875)">
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|
<g
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id="use1340-5"
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transform="translate(42.956753,14.745141)">
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<path
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</g>
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<g
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style="stroke:none" />
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</g>
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</g>
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<g
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style="fill:#000000;fill-opacity:0.8471"
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id="g1364-6"
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transform="matrix(1.3333334,0,0,1.3333334,-87.691054,29.24875)">
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<g
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id="use1358-1"
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transform="translate(293.50452,16.063814)">
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<path
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d="M 0.46875,0 V -4.296875 H 1.9375 c 0.332031,0 0.585938,0.023437 0.765625,0.0625 0.25,0.054687 0.460937,0.15625 0.640625,0.3125 0.21875,0.1875 0.382812,0.433594 0.5,0.734375 0.113281,0.292969 0.171875,0.632812 0.171875,1.015625 0,0.324219 -0.042969,0.617187 -0.125,0.875 -0.074219,0.25 -0.171875,0.460937 -0.296875,0.625 -0.117188,0.15625 -0.246094,0.289063 -0.390625,0.390625 -0.136719,0.09375 -0.304687,0.167969 -0.5,0.21875 C 2.503906,-0.0195312 2.273438,0 2.015625,0 Z m 0.5625,-0.5 h 0.921875 c 0.28125,0 0.5,-0.023438 0.65625,-0.078125 C 2.773438,-0.640625 2.90625,-0.71875 3,-0.8125 3.132812,-0.945312 3.238281,-1.125 3.3125,-1.34375 3.382812,-1.570312 3.421875,-1.851562 3.421875,-2.1875 c 0,-0.445312 -0.074219,-0.789062 -0.21875,-1.03125 C 3.054688,-3.457031 2.878906,-3.617188 2.671875,-3.703125 2.515625,-3.753906 2.269531,-3.78125 1.9375,-3.78125 H 1.03125 Z m 0,0"
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</g>
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<g
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</g>
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<g
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id="use1362-2"
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transform="translate(300.76682,16.063814)">
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style="stroke:none" />
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</g>
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<g
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clip-path="url(#clip8-3)"
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d="M -9.992266,6.827687 H 3581623.1"
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transform="matrix(5.76696e-5,0,0,5.76696e-5,45.84042,25.2457)"
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sodipodi:nodetypes="cc" />
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</g>
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inkscape:connector-curvature="0"
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d="M 96.44483,53.32821 V 77.49354"
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id="path2224-7" />
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<path
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inkscape:connector-curvature="0"
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style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
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d="M 310.8336,53.32821 V 77.49354"
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id="path2228-6" />
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<path
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inkscape:connector-curvature="0"
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style="fill:none;stroke:#000000;stroke-width:0.976538;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:8;stroke-opacity:1"
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d="M 35.008366,52.49576 V 76.66109"
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id="path2224-3-9" />
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<text
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xml:space="preserve"
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style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
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x="35.008366"
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id="text84874"><tspan
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sodipodi:role="line"
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id="tspan84872"
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x="35.008366"
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y="85.631821"
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style="text-align:center;text-anchor:middle">Activate</tspan><tspan
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sodipodi:role="line"
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x="35.008366"
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y="95.631821"
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id="tspan173168"
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style="text-align:center;text-anchor:middle">(bead or DMS)</tspan></text>
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<text
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xml:space="preserve"
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|
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
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x="76.364754"
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y="89.102524"
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id="text86396"><tspan
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sodipodi:role="line"
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id="tspan86394"
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x="76.364754"
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y="89.102524">Transduce</tspan></text>
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<text
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xml:space="preserve"
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style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
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|
x="287.78479"
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y="88.184555"
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id="text89754"><tspan
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id="tspan89752"
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x="287.78479"
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y="88.184555">Harvest/QC</tspan></text>
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<text
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xml:space="preserve"
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|
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
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|
x="215.9864"
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y="88.184555"
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id="text89754-4"><tspan
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id="tspan89752-5"
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x="215.9864"
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y="88.184555">Harvest/QC</tspan></text>
|
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|
<text
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|
xml:space="preserve"
|
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|
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
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|
x="143.99747"
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y="88.184555"
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id="text89754-4-0"><tspan
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sodipodi:role="line"
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id="tspan89752-5-3"
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x="143.99747"
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y="88.184555">Harvest/QC</tspan></text>
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|
<text
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|
xml:space="preserve"
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|
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
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|
x="90.796394"
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y="49.013107"
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id="text100374"><tspan
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id="tspan100372"
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x="90.796394"
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y="49.013107">D1</tspan></text>
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<path
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d="M 167.04629,53.328212 V 77.49354"
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id="path2224-7-3" />
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<text
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xml:space="preserve"
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|
style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
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|
x="161.28067"
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id="text100374-1"><tspan
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y="50.667171">D6</tspan></text>
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id="path2224-7-3-4" />
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<text
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xml:space="preserve"
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style="font-size:8px;line-height:1.25;font-family:sans-serif;letter-spacing:0px"
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|
x="230.73836"
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id="text100374-1-7"><tspan
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y="50.667171">D10</tspan></text>
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<path
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id="path102106"
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sodipodi:nodetypes="cccc" />
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<path
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style="fill:none;stroke:#ff0000;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;marker-end:url(#Arrow2Mend-6)"
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<path
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After Width: | Height: | Size: 32 KiB |
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@ -0,0 +1,10 @@
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\begin{tabular}{lcc}
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\\[-1.8ex]\hline
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\hline \\[-1.8ex]
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\\[-1.8ex] & Dose & 1e6 T cells/mouse & 1e6 CAR T cells/mouse 1e6 (DMS) & CAR T cells/mouse (Bead) \\
|
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|
\hline \\[-1.8ex]
|
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|
High & 1.25 & 0.855 & 0.315 \\
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Medium & 0.8325 & 0.570 & 0.210 \\
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Low & 3.313 & 0.214 & 0.079 \\
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\hline \\[-1.8ex]
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|
\end{tabular}
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@ -1599,6 +1599,23 @@ analyzed using GraphPad Prism using the Mantel-Cox test to assess significance
|
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between survival groups.
|
between survival groups.
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|
||||||
\section{results}
|
\section{results}
|
||||||
|
|
||||||
|
\subsection{DMS-expanded T cells show greater anti-tumor activity \invivo{}
|
||||||
|
compared to beads}
|
||||||
|
|
||||||
|
% figure showing the experimental model and dosing strategy
|
||||||
|
% table for % CAR+ T cells injected into the mice
|
||||||
|
% figure for the mem and CAR+ percent injected into the mice
|
||||||
|
% figure showing IVIS images
|
||||||
|
% figure showing the surival curves
|
||||||
|
|
||||||
|
\subsection{Beads and DMSs perform similarly at earlier timepoints}
|
||||||
|
|
||||||
|
% figure showing the experimental model and dosing strategy
|
||||||
|
% figure for the mem and CAR+ percent injected into the mice
|
||||||
|
% figure showing IVIS images
|
||||||
|
% figure showing the photon plots per time
|
||||||
|
|
||||||
\section{discussion}
|
\section{discussion}
|
||||||
|
|
||||||
\chapter{conclusions and future work}\label{conclusions}
|
\chapter{conclusions and future work}\label{conclusions}
|
||||||
|
|
|
||||||
Loading…
Reference in New Issue