ENH integrate tables and figs into aim 3
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@ -1,7 +1,7 @@
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\begin{tabular}{lcc}
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\begin{tabular}{lccc}
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\\[-1.8ex]\hline
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\\[-1.8ex]\hline
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\hline \\[-1.8ex]
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\hline \\[-1.8ex]
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\\[-1.8ex] & Dose & 1e6 T cells/mouse & 1e6 CAR T cells/mouse 1e6 (DMS) & CAR T cells/mouse (Bead) \\
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\\[-1.8ex] Dose & 1e6 T cells/mouse & 1e6 CAR T cells/mouse 1e6 (DMS) & CAR T cells/mouse (Bead) \\
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\hline \\[-1.8ex]
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\hline \\[-1.8ex]
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High & 1.25 & 0.855 & 0.315 \\
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High & 1.25 & 0.855 & 0.315 \\
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Medium & 0.8325 & 0.570 & 0.210 \\
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Medium & 0.8325 & 0.570 & 0.210 \\
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130
tex/thesis.tex
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tex/thesis.tex
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@ -1603,18 +1603,130 @@ between survival groups.
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\subsection{DMS-expanded T cells show greater anti-tumor activity \invivo{}
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\subsection{DMS-expanded T cells show greater anti-tumor activity \invivo{}
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compared to beads}
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compared to beads}
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% figure showing the experimental model and dosing strategy
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\begin{figure*}[ht!]
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% table for % CAR+ T cells injected into the mice
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\begingroup
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% figure for the mem and CAR+ percent injected into the mice
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% figure showing IVIS images
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\includegraphics{../figures/mouse_dosing_overview.png}
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% figure showing the surival curves
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\endgroup
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\caption[Mouse Dosing Experimental Overview]
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{Overview of \invivo{} experiment to test \gls{car} T cells expanded with
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either \glspl{dms} at different doses. }
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\label{fig:mouse_dosing_overview}
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\end{figure*}
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\begin{table}[!h] \centering
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\caption{Results for \gls{car} T cell \invivo{} dose study}
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\label{tab:mouse_dosing_results}
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\input{../tables/mouse_dose_car.tex}
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\end{table}
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% TODO put growth first in this figure
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\begin{figure*}[ht!]
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\begingroup
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\includegraphics{../figures/mouse_dosing_qc.png}
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\phantomsubcaption\label{fig:mouse_dosing_qc_mem}
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\phantomsubcaption\label{fig:mouse_dosing_qc_cd4}
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\phantomsubcaption\label{fig:mouse_dosing_qc_growth}
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\endgroup
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\caption[Mouse Dosing T cell Characteristics]
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{Characteristics of T cells harvested at day 14 injected into NSG
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mice at varying doses.
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Fractions of T cell subtypes in the day 14 product including
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\subcap{fig:mouse_dosing_qc_mem}{\ptmemp{}}.
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\subcap{fig:mouse_dosing_qc_cd4}{\pthp{}}, and
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\subcap{fig:mouse_dosing_qc_growth}{Fold change of T cells.}
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}
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\label{fig:mouse_dosing_qc}
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\end{figure*}
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% TODO explain what statistical test was used here
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\begin{figure*}[ht!]
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\begingroup
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\includegraphics{../figures/mouse_dosing_ivis.png}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_images}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_plots}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_survival}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_survival_comp}
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\endgroup
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\caption[Mouse Dosing IVIS and Survival Results]
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{T cells expanded with \glspl{dms} confer greater anti-tumor potency \invivo{}
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even at lower doses.
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\subcap{fig:mouse_dosing_ivis_images}{IVIS images of Nalm-6 tumor-bearing
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\gls{nsg} mice injected with varying doses of T cells}
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\subcap{fig:mouse_dosing_ivis_plots}{Plots showing quantified photon counts
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of the results from (\subref{fig:mouse_dosing_ivis_plots}).}
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\subcap{fig:mouse_dosing_ivis_survival}{Survival plots of mice}
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\subcap{fig:mouse_dosing_ivis_survival_comp}{Survival plots of mice showing
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only those that received a comparable number of \gls{car} T cells.}
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}
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\label{fig:mouse_dosing_ivis}
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\end{figure*}
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\subsection{Beads and DMSs perform similarly at earlier timepoints}
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\subsection{Beads and DMSs perform similarly at earlier timepoints}
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% figure showing the experimental model and dosing strategy
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\begin{figure*}[ht!]
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% figure for the mem and CAR+ percent injected into the mice
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\begingroup
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% figure showing IVIS images
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% figure showing the photon plots per time
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\includegraphics{../figures/mouse_timecourse_overview.png}
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\endgroup
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\caption[Mouse Timecourse Experimental Overview]
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{Overview of \invivo{} experiment to test \gls{car} T cells using either
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\glspl{dms} or bead harvested at varying timepoints.
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}
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\label{fig:mouse_timecourse_overview}
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\end{figure*}
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\begin{figure*}[ht!]
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\begingroup
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\includegraphics{../figures/mouse_timecourse_qc.png}
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\phantomsubcaption\label{fig:mouse_timecourse_qc_growth}
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\phantomsubcaption\label{fig:mouse_timecourse_qc_car}
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\phantomsubcaption\label{fig:mouse_timecourse_qc_cd4}
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\phantomsubcaption\label{fig:mouse_timecourse_qc_mem}
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\endgroup
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\caption[Mouse Timecourse T cell Characteristics]
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{Characteristics of T cells harvested at varying timepoints injected into NSG
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mice.
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\subcap{fig:mouse_timecourse_qc_growth}{Fold change of T cells (each
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timepoint only includes the runs that were harvested at day 14).}
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Fractions of T cell subtypes in the day 14 product including
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% TODO refactor CAR+ percent into nice macro
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\subcap{fig:mouse_timecourse_qc_car}{\gls{car}+~\si{\percent}},
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\subcap{fig:mouse_timecourse_qc_cd4}{\pthp{}}, and
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\subcap{fig:mouse_timecourse_qc_mem}{\ptmemp{}}.
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}
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\label{fig:mouse_timecourse_qc}
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\end{figure*}
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\begin{figure*}[ht!]
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\begingroup
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\includegraphics{../figures/mouse_timecourse_ivis.png}
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\phantomsubcaption\label{fig:mouse_timecourse_ivis_images}
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\phantomsubcaption\label{fig:mouse_timecourse_ivis_plots}
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\endgroup
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\caption[Mouse Timecourse IVIS Results]
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{\glspl{dms} exhibit superior anti-tumor activity \invivo{} at day 14 compared
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to beads but are similar to beads at lower timepoints.
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\subcap{fig:mouse_timecourse_ivis_images}{IVIS images for day 6 to day 42 of
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mice treated with varying doses of \gls{car} T cells grown with beads or
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\glspl{dms}.}
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\subcap{fig:mouse_timecourse_ivis_plots}{Quantified dotplots of the images
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in (\subref{fig:mouse_timecourse_ivis_images}). Numbers beneath each dot
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represent the number of mice at that timepoint.},
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}
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\label{fig:mouse_timecourse_ivis}
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\end{figure*}
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\section{discussion}
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\section{discussion}
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