ENH integrate tables and figs into aim 3

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Nathan Dwarshuis 2021-07-26 13:50:51 -04:00
parent ddb623424e
commit e329f072db
4 changed files with 123 additions and 11 deletions

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\begin{tabular}{lcc} \begin{tabular}{lccc}
\\[-1.8ex]\hline \\[-1.8ex]\hline
\hline \\[-1.8ex] \hline \\[-1.8ex]
\\[-1.8ex] & Dose & 1e6 T cells/mouse & 1e6 CAR T cells/mouse 1e6 (DMS) & CAR T cells/mouse (Bead) \\ \\[-1.8ex] Dose & 1e6 T cells/mouse & 1e6 CAR T cells/mouse 1e6 (DMS) & CAR T cells/mouse (Bead) \\
\hline \\[-1.8ex] \hline \\[-1.8ex]
High & 1.25 & 0.855 & 0.315 \\ High & 1.25 & 0.855 & 0.315 \\
Medium & 0.8325 & 0.570 & 0.210 \\ Medium & 0.8325 & 0.570 & 0.210 \\

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@ -1603,18 +1603,130 @@ between survival groups.
\subsection{DMS-expanded T cells show greater anti-tumor activity \invivo{} \subsection{DMS-expanded T cells show greater anti-tumor activity \invivo{}
compared to beads} compared to beads}
% figure showing the experimental model and dosing strategy \begin{figure*}[ht!]
% table for % CAR+ T cells injected into the mice \begingroup
% figure for the mem and CAR+ percent injected into the mice
% figure showing IVIS images \includegraphics{../figures/mouse_dosing_overview.png}
% figure showing the surival curves
\endgroup
\caption[Mouse Dosing Experimental Overview]
{Overview of \invivo{} experiment to test \gls{car} T cells expanded with
either \glspl{dms} at different doses. }
\label{fig:mouse_dosing_overview}
\end{figure*}
\begin{table}[!h] \centering
\caption{Results for \gls{car} T cell \invivo{} dose study}
\label{tab:mouse_dosing_results}
\input{../tables/mouse_dose_car.tex}
\end{table}
% TODO put growth first in this figure
\begin{figure*}[ht!]
\begingroup
\includegraphics{../figures/mouse_dosing_qc.png}
\phantomsubcaption\label{fig:mouse_dosing_qc_mem}
\phantomsubcaption\label{fig:mouse_dosing_qc_cd4}
\phantomsubcaption\label{fig:mouse_dosing_qc_growth}
\endgroup
\caption[Mouse Dosing T cell Characteristics]
{Characteristics of T cells harvested at day 14 injected into NSG
mice at varying doses.
Fractions of T cell subtypes in the day 14 product including
\subcap{fig:mouse_dosing_qc_mem}{\ptmemp{}}.
\subcap{fig:mouse_dosing_qc_cd4}{\pthp{}}, and
\subcap{fig:mouse_dosing_qc_growth}{Fold change of T cells.}
}
\label{fig:mouse_dosing_qc}
\end{figure*}
% TODO explain what statistical test was used here
\begin{figure*}[ht!]
\begingroup
\includegraphics{../figures/mouse_dosing_ivis.png}
\phantomsubcaption\label{fig:mouse_dosing_ivis_images}
\phantomsubcaption\label{fig:mouse_dosing_ivis_plots}
\phantomsubcaption\label{fig:mouse_dosing_ivis_survival}
\phantomsubcaption\label{fig:mouse_dosing_ivis_survival_comp}
\endgroup
\caption[Mouse Dosing IVIS and Survival Results]
{T cells expanded with \glspl{dms} confer greater anti-tumor potency \invivo{}
even at lower doses.
\subcap{fig:mouse_dosing_ivis_images}{IVIS images of Nalm-6 tumor-bearing
\gls{nsg} mice injected with varying doses of T cells}
\subcap{fig:mouse_dosing_ivis_plots}{Plots showing quantified photon counts
of the results from (\subref{fig:mouse_dosing_ivis_plots}).}
\subcap{fig:mouse_dosing_ivis_survival}{Survival plots of mice}
\subcap{fig:mouse_dosing_ivis_survival_comp}{Survival plots of mice showing
only those that received a comparable number of \gls{car} T cells.}
}
\label{fig:mouse_dosing_ivis}
\end{figure*}
\subsection{Beads and DMSs perform similarly at earlier timepoints} \subsection{Beads and DMSs perform similarly at earlier timepoints}
% figure showing the experimental model and dosing strategy \begin{figure*}[ht!]
% figure for the mem and CAR+ percent injected into the mice \begingroup
% figure showing IVIS images
% figure showing the photon plots per time \includegraphics{../figures/mouse_timecourse_overview.png}
\endgroup
\caption[Mouse Timecourse Experimental Overview]
{Overview of \invivo{} experiment to test \gls{car} T cells using either
\glspl{dms} or bead harvested at varying timepoints.
}
\label{fig:mouse_timecourse_overview}
\end{figure*}
\begin{figure*}[ht!]
\begingroup
\includegraphics{../figures/mouse_timecourse_qc.png}
\phantomsubcaption\label{fig:mouse_timecourse_qc_growth}
\phantomsubcaption\label{fig:mouse_timecourse_qc_car}
\phantomsubcaption\label{fig:mouse_timecourse_qc_cd4}
\phantomsubcaption\label{fig:mouse_timecourse_qc_mem}
\endgroup
\caption[Mouse Timecourse T cell Characteristics]
{Characteristics of T cells harvested at varying timepoints injected into NSG
mice.
\subcap{fig:mouse_timecourse_qc_growth}{Fold change of T cells (each
timepoint only includes the runs that were harvested at day 14).}
Fractions of T cell subtypes in the day 14 product including
% TODO refactor CAR+ percent into nice macro
\subcap{fig:mouse_timecourse_qc_car}{\gls{car}+~\si{\percent}},
\subcap{fig:mouse_timecourse_qc_cd4}{\pthp{}}, and
\subcap{fig:mouse_timecourse_qc_mem}{\ptmemp{}}.
}
\label{fig:mouse_timecourse_qc}
\end{figure*}
\begin{figure*}[ht!]
\begingroup
\includegraphics{../figures/mouse_timecourse_ivis.png}
\phantomsubcaption\label{fig:mouse_timecourse_ivis_images}
\phantomsubcaption\label{fig:mouse_timecourse_ivis_plots}
\endgroup
\caption[Mouse Timecourse IVIS Results]
{\glspl{dms} exhibit superior anti-tumor activity \invivo{} at day 14 compared
to beads but are similar to beads at lower timepoints.
\subcap{fig:mouse_timecourse_ivis_images}{IVIS images for day 6 to day 42 of
mice treated with varying doses of \gls{car} T cells grown with beads or
\glspl{dms}.}
\subcap{fig:mouse_timecourse_ivis_plots}{Quantified dotplots of the images
in (\subref{fig:mouse_timecourse_ivis_images}). Numbers beneath each dot
represent the number of mice at that timepoint.},
}
\label{fig:mouse_timecourse_ivis}
\end{figure*}
\section{discussion} \section{discussion}