ADD full survival curve to first mouse experiment
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@ -1960,15 +1960,16 @@ of both the bead medium dose and the bead high dose
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of Nalm-6 tumor bearing \gls{nsg} mice shown in the
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of Nalm-6 tumor bearing \gls{nsg} mice shown in the
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\cref{fig:mouse_dosing_ivis_survival} was up to day 40 as reported
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\cref{fig:mouse_dosing_ivis_survival} was up to day 40 as reported
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elsewhere\cite{Fraietta2018}. However, we also included a Kaplan-Meier figure up
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elsewhere\cite{Fraietta2018}. However, we also included a Kaplan-Meier figure up
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to day 46 (Supplemental Figure 7) where most of the mice euthanized from day 40
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to day 46 (\cref{fig:mouse_dosing_ivis_survival_full}) where most of the mice
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through day 46 from \gls{dms} groups showed no or very small fragment of spleen
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euthanized from day 40 through day 46 from \gls{dms} groups showed no or very
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which was due to \gls{gvhd} responses. Similar \gls{gvhd} responses were
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small fragment of spleen which was due to \gls{gvhd} responses. Similar
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reported earlier in \gls{nsg} mice where the mice injected with human \gls{pbmc}
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\gls{gvhd} responses were reported earlier in \gls{nsg} mice where the mice
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exhibited acute \gls{gvhd} between \SIrange{40}{50}{\day} post intravenous
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injected with human \gls{pbmc} exhibited acute \gls{gvhd} between
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injection\cite{Ali2012}. Notably, both survival analyses (up to day 40 in
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\SIrange{40}{50}{\day} post intravenous injection\cite{Ali2012}. Notably, both
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\cref{fig:mouse_dosing_ivis_survival} and up to day 46 in Supplemental Figure 7)
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survival analyses (up to day 40 in \cref{fig:mouse_dosing_ivis_survival} and up
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confirmed that \gls{dms}-expanded groups outperformed bead-expanded groups in
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to day 46 in \cref{fig:mouse_dosing_ivis_survival_full}) confirmed that
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terms of prolonging survival of Nalm-6 tumor challenged \gls{nsg} mice.
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\gls{dms}-expanded groups outperformed bead-expanded groups in terms of
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prolonging survival of Nalm-6 tumor challenged \gls{nsg} mice.
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Together, these data suggested that \glspl{dms} produce T cells that are not
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Together, these data suggested that \glspl{dms} produce T cells that are not
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only more potent that bead-expanded T cells (even when accounting for
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only more potent that bead-expanded T cells (even when accounting for
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@ -2026,6 +2027,7 @@ cells are effective at lower doses.
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\phantomsubcaption\label{fig:mouse_dosing_ivis_plots}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_plots}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_survival}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_survival}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_survival_comp}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_survival_comp}
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\phantomsubcaption\label{fig:mouse_dosing_ivis_survival_full}
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\endgroup
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\endgroup
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\caption[Mouse Dosing IVIS and Survival Results]
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\caption[Mouse Dosing IVIS and Survival Results]
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@ -2038,6 +2040,9 @@ cells are effective at lower doses.
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\subcap{fig:mouse_dosing_ivis_survival}{Survival plots of mice}
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\subcap{fig:mouse_dosing_ivis_survival}{Survival plots of mice}
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\subcap{fig:mouse_dosing_ivis_survival_comp}{Survival plots of mice showing
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\subcap{fig:mouse_dosing_ivis_survival_comp}{Survival plots of mice showing
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only those that received a comparable number of \gls{car} T cells.}
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only those that received a comparable number of \gls{car} T cells.}
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\subcap{fig:mouse_dosing_ivis_survival_full}{The same data as
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\subref{fig:mouse_dosing_ivis_survival} except showing the full time until
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euthanasia for all mice (including those that died via \gls{gvhd}).}
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}
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}
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\label{fig:mouse_dosing_ivis}
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\label{fig:mouse_dosing_ivis}
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\end{figure*}
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\end{figure*}
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