ADD inside carrier figure and phenotype figure
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@ -139,6 +139,8 @@
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\newcommand{\subcap}[2]{\subref{#1}) #2}
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\newcommand{\subcap}[2]{\subref{#1}) #2}
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\newcommand{\sigkey}{Significance test key: *p<0.1; **p < 0.05; ***p<0.01}
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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% ditto for environments
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% ditto for environments
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@ -992,11 +994,32 @@ context of pure error). Statistical significance was evaluated at $\upalpha$ =
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\label{fig:dms_cells}
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\label{fig:dms_cells}
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\end{figure*}
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\end{figure*}
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% 3-donor expansion figure
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% TODO add this to the methods section
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% TODO double check the timing of this experiment (it might not be day 14)
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% TODO provide the regression results and coefficients from this
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\begin{figure*}[ht!]
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\begingroup
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\includegraphics{../figures/dms_inside.png}
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\phantomsubcaption\label{fig:dms_inside_bf}
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\phantomsubcaption\label{fig:dms_inside_regression}
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\endgroup
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\caption[A subset of T cells grow in interior of \glspl{dms}]
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{A percentage of T cells grow in the interior of \glspl{dms}.
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\subcap{fig:dms_inside_bf}{T cells stained dark with MTT after growing on
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either coated or uncoated \glspl{dms} for 14 days visualized with
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brightfield microscope.}
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\subcap{fig:dms_inside_regression}{Linear regression performed on T cell
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percentages harvested on the interior of the \glspl{dms} vs the initial
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starting cell density.}
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}
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\label{fig:dms_inside}
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\end{figure*}
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\subsection{DMSs lead to greater expansion and memory and CD4+ phenotypes}
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\subsection{DMSs lead to greater expansion and memory and CD4+ phenotypes}
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% TODO add significance tests to this
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\begin{figure*}[ht!]
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\begin{figure*}[ht!]
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\begingroup
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\begingroup
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@ -1019,12 +1042,29 @@ context of pure error). Statistical significance was evaluated at $\upalpha$ =
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\subcap{fig:dms_exp_mem}{\ptmem{} cells},
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\subcap{fig:dms_exp_mem}{\ptmem{} cells},
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\subcap{fig:dms_exp_cd4}{\pth{} cells},
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\subcap{fig:dms_exp_cd4}{\pth{} cells},
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\subcap{fig:dms_exp_mem4}{\ptmemh{} cells}, and
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\subcap{fig:dms_exp_mem4}{\ptmemh{} cells}, and
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\subcap{fig:dms_exp_mem8}{\ptmemk{} cells}
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\subcap{fig:dms_exp_mem8}{\ptmemk{} cells}. \sigkey{}
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}
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}
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\label{fig:dms_exp}
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\label{fig:dms_exp}
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\end{figure*}
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\end{figure*}
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% phenotype flow plots
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% TODO this figure has weird proportions
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\begin{figure*}[ht!]
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\begingroup
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\includegraphics{../figures/dms_phenotypes.png}
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\phantomsubcaption\label{fig:dms_phenotype_mem}
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\phantomsubcaption\label{fig:dms_phenotype_cd4}
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\endgroup
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\caption[Representative flow plots of \ptmem{} and \pth{} T cells]
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{Representative flow plots of \ptmem{} and \pth{} T cells at day 14 of
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expansion using either beads or \glspl{dms}. For three representative donor
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samples, phenotypes are shown for \subcap{fig:dms_phenotype_mem}{\ptmem{}}
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and \subcap{fig:dms_phenotype_cd4}{\pth}. Each population was also gated on
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\cdp{3} T cells.
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}
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\label{fig:dms_phenotype}
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\end{figure*}
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\subsection*{DMSs can be used to produce functional CAR T cells}
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\subsection*{DMSs can be used to produce functional CAR T cells}
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