ADD footnote explaining that these aren't the donors you are looking for
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@ -2321,8 +2321,6 @@ cells to a greater degree than beads \cref{fig:dms_exp_cd4}. The trends held
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true when observing the CD4+ and CD8+ fractions of the naïve/memory subset
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true when observing the CD4+ and CD8+ fractions of the naïve/memory subset
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(\ptmem{}) (\cref{fig:dms_exp_mem4,fig:dms_exp_mem8}).
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(\ptmem{}) (\cref{fig:dms_exp_mem4,fig:dms_exp_mem8}).
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% FIGURE this figure was not produced with the same donors as the figure above,
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% which is really confusing
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\begin{figure*}[ht!]
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\begin{figure*}[ht!]
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\begingroup
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\begingroup
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@ -2345,20 +2343,21 @@ We also observed that, at least with the donors and conditions tested in these
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experiments\footnote{these results were not always consistent, see the
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experiments\footnote{these results were not always consistent, see the
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metaanalysis at the end of this aim for an in-depth quantification of this
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metaanalysis at the end of this aim for an in-depth quantification of this
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observation} that the fraction of \ptmem{} and \pth{} T cells was higher in
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observation} that the fraction of \ptmem{} and \pth{} T cells was higher in
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the \gls{dms} groups compared to the bead groups (\cref{fig:dms_phenotype}).
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the \gls{dms} groups compared to the bead groups
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This result was seen for multiple donors. We should note that in the case of
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(\cref{fig:dms_phenotype})\footnote{these where not the same donors as used for
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\pthp{}, the donors we used had an initial \pthp{} that was much higher (healthy
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\cref{fig:dms_exp}}. This result was seen for multiple donors. We should note
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donors generally have a CD4:CD8 ratio of 2:1), so the proper interpretation of
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that in the case of \pthp{}, the donors we used had an initial \pthp{} that was
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this is that the \pthp{} decreases less over the culture period with the
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much higher (healthy donors generally have a CD4:CD8 ratio of 2:1), so the
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\gls{dms} platform as opposed to the beads (or alternatively, the \gls{dms} has
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proper interpretation of this is that the \pthp{} decreases less over the
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less preferential expansion for CD8 T cells). We cannot say the same about
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culture period with the \gls{dms} platform as opposed to the beads (or
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the \ptmemp{} since we did not have the initial data for this phenotype;
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alternatively, the \gls{dms} has less preferential expansion for CD8 T cells).
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however (although it should be the vast majority of cells given that
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We cannot say the same about the \ptmemp{} since we did not have the initial
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cryopreserved T cells from a healthy donor should generally be composed of
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data for this phenotype; however (although it should be the vast majority of
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circulated memory and naive T cells). Taken together, these data indicate the
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cells given that cryopreserved T cells from a healthy donor should generally be
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\gls{dms} platform has the capacity to expand higher numbers and percentages of
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composed of circulated memory and naive T cells). Taken together, these data
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highly potent \ptmem{} and \pth{} T cells compared to state-of-the-art bead
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indicate the \gls{dms} platform has the capacity to expand higher numbers and
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technology.
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percentages of highly potent \ptmem{} and \pth{} T cells compared to
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state-of-the-art bead technology.
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\subsection*{DMSs can be used to produce functional CAR T cells}
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\subsection*{DMSs can be used to produce functional CAR T cells}
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