ADD small para on bcma
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@ -97,6 +97,7 @@
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\newacronym{gvhd}{GVHD}{graft-vs-host disease}
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\newacronym{gvhd}{GVHD}{graft-vs-host disease}
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\newacronym{bcma}{BCMA}{B-cell maturation antigen}
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\newacronym{bcma}{BCMA}{B-cell maturation antigen}
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\newacronym{di}{DI}{deionized}
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\newacronym{di}{DI}{deionized}
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\newacronym{moi}{MOI}{multiplicity of infection}
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
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% SI units for uber nerds
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% SI units for uber nerds
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@ -160,7 +161,8 @@
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\newcommand{\ptmemh}{\pth\ptmem}
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\newcommand{\ptmemh}{\pth\ptmem}
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\newcommand{\ptmemk}{\ptk\ptmem}
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\newcommand{\ptmemk}{\ptk\ptmem}
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\newcommand{\dpthp}{$\Updelta$\pthp{}}
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\newcommand{\dpthp}{$\Updelta$\pthp{}}
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\newcommand{\carp}{\gls{car}+~\si{\percent}}
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\newcommand{\ptcar}{\gls{car}+}
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\newcommand{\ptcarp}{\ptcar~\si{\percent}}
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\newcommand{\catnum}[2]{(#1, #2)}
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\newcommand{\catnum}[2]{(#1, #2)}
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\newcommand{\product}[3]{#1 \catnum{#2}{#3}}
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\newcommand{\product}[3]{#1 \catnum{#2}{#3}}
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@ -1433,7 +1435,13 @@ showing that migration was likely independent of \gls{car} transduction.
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\label{fig:car_production}
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\label{fig:car_production}
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\end{figure*}
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\end{figure*}
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% RESULT bcma stuff
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In addition to CD19 \gls{car} T cells, we also demonstrated that the \gls{dms}
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platform can be used to expand \gls{car} T cells against \gls{bcma}. Analogously
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to the case with CD19, \gls{dms} and bead produced similar fractions of \ptcar{}
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cells (albeit in this case at day 7 and with an undefined \gls{moi})
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(\cref{fig:car_bcma_percent}). Also consistent with CD19 and non-\gls{car} data,
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we also found that the number of \ptcar{} T cells was greater for \gls{dms} than
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for bead (\cref{fig:car_bcma_total}).
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% TODO the right half if bigger than the left half
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% TODO the right half if bigger than the left half
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% TODO add memory stuff to this since I have it (it wasn't the right size so I
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% TODO add memory stuff to this since I have it (it wasn't the right size so I
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@ -1449,8 +1457,8 @@ showing that migration was likely independent of \gls{car} transduction.
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\caption[BMCA Transduction Results]
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\caption[BMCA Transduction Results]
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{\glspl{dms} produce larger numbers of \gls{bcma} \gls{car} T cells compared
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{\glspl{dms} produce larger numbers of \gls{bcma} \gls{car} T cells compared
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to beads.
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to beads.
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\subcap{fig:car_bcma_percent}{\carp{} at day 14.}
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\subcap{fig:car_bcma_percent}{\ptcarp{} at day 14.}
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\subcap{fig:car_bcma_total}{Total number of \carp{} cells at day 14.}
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\subcap{fig:car_bcma_total}{Total number of \ptcarp{} cells at day 14.}
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}
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}
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\label{fig:car_bcma}
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\label{fig:car_bcma}
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\end{figure*}
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\end{figure*}
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@ -2267,7 +2275,7 @@ cells are effective at lower doses.
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\subcap{fig:mouse_timecourse_qc_growth}{Fold change of T cells (each
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\subcap{fig:mouse_timecourse_qc_growth}{Fold change of T cells (each
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timepoint only includes the runs that were harvested at day 14).}
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timepoint only includes the runs that were harvested at day 14).}
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Fractions of T cell subtypes in the day 14 product including
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Fractions of T cell subtypes in the day 14 product including
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\subcap{fig:mouse_timecourse_qc_car}{\carp{}},
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\subcap{fig:mouse_timecourse_qc_car}{\ptcarp{}},
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\subcap{fig:mouse_timecourse_qc_cd4}{\pthp{}}, and
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\subcap{fig:mouse_timecourse_qc_cd4}{\pthp{}}, and
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\subcap{fig:mouse_timecourse_qc_mem}{\ptmemp{}}.
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\subcap{fig:mouse_timecourse_qc_mem}{\ptmemp{}}.
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}
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}
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