ndwarshuis
/
phd_thesis
1
0
Fork 0
Code Issues Pull Requests Packages Projects Releases Wiki Activity

ADD small para on bcma

This commit is contained in:
Nathan Dwarshuis 2021-07-27 17:53:07 -04:00
parent ca3a1b9651
commit 67a4758da0
1 changed files with 13 additions and 5 deletions
Show Stats Download Patch File Download Diff File Expand all files Collapse all files

18
tex/thesis.tex
View File

@ -97,6 +97,7 @@
\newacronym{gvhd}{GVHD}{graft-vs-host disease}
\newacronym{bcma}{BCMA}{B-cell maturation antigen}
\newacronym{di}{DI}{deionized}
\newacronym{moi}{MOI}{multiplicity of infection}
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
% SI units for uber nerds
@ -160,7 +161,8 @@
\newcommand{\ptmemh}{\pth\ptmem}
\newcommand{\ptmemk}{\ptk\ptmem}
\newcommand{\dpthp}{$\Updelta$\pthp{}}
\newcommand{\carp}{\gls{car}+~\si{\percent}}
\newcommand{\ptcar}{\gls{car}+}
\newcommand{\ptcarp}{\ptcar~\si{\percent}}
\newcommand{\catnum}[2]{(#1, #2)}
\newcommand{\product}[3]{#1 \catnum{#2}{#3}}
@ -1433,7 +1435,13 @@ showing that migration was likely independent of \gls{car} transduction.
\label{fig:car_production}
\end{figure*}
% RESULT bcma stuff
In addition to CD19 \gls{car} T cells, we also demonstrated that the \gls{dms}
platform can be used to expand \gls{car} T cells against \gls{bcma}. Analogously
to the case with CD19, \gls{dms} and bead produced similar fractions of \ptcar{}
cells (albeit in this case at day 7 and with an undefined \gls{moi})
(\cref{fig:car_bcma_percent}). Also consistent with CD19 and non-\gls{car} data,
we also found that the number of \ptcar{} T cells was greater for \gls{dms} than
for bead (\cref{fig:car_bcma_total}).
% TODO the right half if bigger than the left half
% TODO add memory stuff to this since I have it (it wasn't the right size so I
@ -1449,8 +1457,8 @@ showing that migration was likely independent of \gls{car} transduction.
\caption[BMCA Transduction Results]
{\glspl{dms} produce larger numbers of \gls{bcma} \gls{car} T cells compared
to beads.
\subcap{fig:car_bcma_percent}{\carp{} at day 14.}
\subcap{fig:car_bcma_total}{Total number of \carp{} cells at day 14.}
\subcap{fig:car_bcma_percent}{\ptcarp{} at day 14.}
\subcap{fig:car_bcma_total}{Total number of \ptcarp{} cells at day 14.}
}
\label{fig:car_bcma}
\end{figure*}
@ -2267,7 +2275,7 @@ cells are effective at lower doses.
\subcap{fig:mouse_timecourse_qc_growth}{Fold change of T cells (each
timepoint only includes the runs that were harvested at day 14).}
Fractions of T cell subtypes in the day 14 product including
\subcap{fig:mouse_timecourse_qc_car}{\carp{}},
\subcap{fig:mouse_timecourse_qc_car}{\ptcarp{}},
\subcap{fig:mouse_timecourse_qc_cd4}{\pthp{}}, and
\subcap{fig:mouse_timecourse_qc_mem}{\ptmemp{}}.
}