ADD discussion to aim 3 mouse 1
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@ -157,6 +157,7 @@
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\newcommand{\ptmemh}{\pth\ptmem}
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\newcommand{\ptmemk}{\ptk\ptmem}
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\newcommand{\dpthp}{$\Updelta$\pthp{}}
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\newcommand{\carp}{\gls{car}+~\si{\percent}}
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\newcommand{\catnum}[2]{(#1, #2)}
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\newcommand{\product}[3]{#1 \catnum{#2}{#3}}
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@ -2072,8 +2073,7 @@ cells are effective at lower doses.
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\subcap{fig:mouse_timecourse_qc_growth}{Fold change of T cells (each
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timepoint only includes the runs that were harvested at day 14).}
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Fractions of T cell subtypes in the day 14 product including
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% TODO refactor CAR+ percent into nice macro
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\subcap{fig:mouse_timecourse_qc_car}{\gls{car}+~\si{\percent}},
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\subcap{fig:mouse_timecourse_qc_car}{\carp{}},
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\subcap{fig:mouse_timecourse_qc_cd4}{\pthp{}}, and
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\subcap{fig:mouse_timecourse_qc_mem}{\ptmemp{}}.
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}
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@ -2103,6 +2103,22 @@ cells are effective at lower doses.
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\section{discussion}
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When we tested bead and DMS expanded \gls{car} T cells, we also found that the
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\gls{dms} expanded CAR-T cells outperformed bead groups in prolonging survival
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of Nalm-6 tumor challenged (intravenously injected) \gls{nsg} mice. DMS expanded
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CAR-T cells were very effective in clearing tumor cells as early as 7 days post
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CAR-T injection even at low total T cell dose compared to the bead groups where
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tumor burden was higher than DMS groups across all the total T cell doses tested
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here. More interestingly, when only CAR-expressing T cell doses between bead and
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DMS groups were compared, DMS group had significantly higher survival effects
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over similar or higher CAR expression T cell doses from bead group. All these
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results suggest that the higher proportion of memory T cells in DMS groups
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(compared to bead group) resulted in highly effective CAR-T cells that can
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efficiently kill tumor cells as recently reported in
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literature\cite{Fraietta2018, Sommermeyer2015}.
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% DISCUSSION 2nd mouse model
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\chapter{conclusions and future work}\label{conclusions}
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\section{conclusions}
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\section{future work}
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